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A multidirectional investigation of stem bark extracts of four African plants: HPLC-MS/MS profiling and biological potentials
Kouadio Bene1; Kouadio Ibrahime Sinan2; Gokhan Zengin2; Alina Diuzheva3; József Jekő4; Zoltán Cziáky4; Muhammad Zakariyyah Aumeeruddy5; Jianbo Xiao6; Mohamad Fawzi Mahomoodally5
2019-05
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN0731-7085
Volume168Pages:217-224
Abstract

The practice of traditional medicine, especially herbal medicine, is still prevalent across the African continent. Yet, their in-depth pharmacological and chemical exploitation by the scientific community remain a necessity. The aim of the present study was to investigate into the phenolic components, antioxidant, and enzyme-inhibitory activities of three solvent extracts (ethyl acetate, methanol, and water) of the stem bark of four African plant species (Senna siamea, Distemonanthus benthamianus, Harrisonia abyssinica,and Pycnanthus angolensis). It was found that D. benthamianus followed by P. angolensis, displayed the highest DPPH and ABTS scavenging, ferric and cupric reducing, and total antioxidant capacity in the phosphomolybdenum assay. A similar result was observed for AChE, BChE, and tyrosinase inhibition. The two plants also showed comparable α-amylase inhibitory effect. On the other hand, H. abyssinica showed high metal chelating and α-glucosidase inhibition. Among the solvents used, the methanol extract seemed to be the most bioactive. In addition, TPC was highest in D. benthamianus (135.33–192.29 mg GAE/g) while P. angolensis was richest in TFC (7.68–12.48 mg RE/g). A range of bioactive compounds were identified in the extracts, with variations observed among the plants. Senna siamea stem bark showed the presence of nine compounds; where flavonoids (e.g. naringenin, kaempferol, dihydroquercetin) were recorded. Genistein (m/z 271.06), procyanidin B (m/z 577.13) and C (m/z 865.19) isomers were common in stem barks extracts of D. benthamianus and P. Angolensis. To conclude, D. benthamianusand P. angolensis can be considered as potential pharmaceutical agents or functional food components that could reduce the risks of oxidative stress-related disorders.

KeywordSenna Siamea Distemonanthus Benthamianus Harrisonia Abyssinica Pycnanthus Angolensis Enzyme Inhibitors Bio-pharmaceutical
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS IDWOS:000463305700025
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Laboratoire de Botanique et Phytothérapie, Unité de Formation et de Recherche Sciences de la Nature, 02 BP 801 Abidjan 02, Université Nangui Abrogoua, Abidjan, Cote d’Ivoire
2.Department of Biology, Science Faculty, Selcuk Universtiy, Campus, Konya, Turkey
3.Department of Analytical Chemistry, Pavol Jozef Šafárik University in Košice, Košice, Slovakia
4.Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, Nyíregyháza, Hungary
5.Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit, Mauritius
6.University of Macau, Institute of Chinese Medical Sciences, Taipa, Macau, China
Recommended Citation
GB/T 7714
Kouadio Bene,Kouadio Ibrahime Sinan,Gokhan Zengin,et al. A multidirectional investigation of stem bark extracts of four African plants: HPLC-MS/MS profiling and biological potentials[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2019,168:217-224.
APA Kouadio Bene.,Kouadio Ibrahime Sinan.,Gokhan Zengin.,Alina Diuzheva.,József Jekő.,...&Mohamad Fawzi Mahomoodally.(2019).A multidirectional investigation of stem bark extracts of four African plants: HPLC-MS/MS profiling and biological potentials.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,168,217-224.
MLA Kouadio Bene,et al."A multidirectional investigation of stem bark extracts of four African plants: HPLC-MS/MS profiling and biological potentials".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 168(2019):217-224.
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