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Sonchus oleraceus Linn protects against LPS-induced sepsis and inhibits inflammatory responses in RAW264.7 cells
Lei Chen; Xiujun Lin; Jianbo Xiao; Yuting Tian; Baodong Zheng; Hui Teng
2019-05
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
Volume236Pages:63-69
Abstract

Ethnopharmacological relevance
Sonchus oleraceus Linn (SOL) belongs to family of Asteraceae, is a traditional medicinal plant, which has been used to treat tumor, inflammatory diseases, infection and so on in Chinese folk culture.


Aim of the study
This work investigated the influence of aqueous ethanol extract of whole plant of SOL and contribution of its main components on inflammation


Methods and results
Oral administration of SOL (10 mg/kg) to mice reduced the expression of inflammatory cytokines including IL-6, IL-1β, and TNF-α, in the LPS-induced sepsis mouse model. Major phenolics in SOL were isolated and determined by HPLC. Results indicate that SOL at the concentration range from 25 to 100 μg/mL and its main components, chlorogenic acid, caffeic acid (25–100 μM) significantly reduced the pro-inflammatory cytokine IL-1β, IL-6, TNF-α, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages. In addition, western blot analysis showed SOL suppressed inducible nitric oxide synthase (iNOS) protein expression and the phosphorylation of extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK).


Conclusion
The underlying mechanism of anti-inflammation might be in according with the inhibition of MAPKs activation as well as down regulation of iNOS and cyclooxygenase-2 (COX-2).

KeywordSonchus Oleraceus Linn Chlorogenic Acid Caffeic Acid Anti-inflammation Mapks
DOI10.1016/j.jep.2019.02.039
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000465049300007
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Recommended Citation
GB/T 7714
Lei Chen,Xiujun Lin,Jianbo Xiao,et al. Sonchus oleraceus Linn protects against LPS-induced sepsis and inhibits inflammatory responses in RAW264.7 cells[J]. JOURNAL OF ETHNOPHARMACOLOGY,2019,236:63-69.
APA Lei Chen,Xiujun Lin,Jianbo Xiao,Yuting Tian,Baodong Zheng,&Hui Teng.(2019).Sonchus oleraceus Linn protects against LPS-induced sepsis and inhibits inflammatory responses in RAW264.7 cells.JOURNAL OF ETHNOPHARMACOLOGY,236,63-69.
MLA Lei Chen,et al."Sonchus oleraceus Linn protects against LPS-induced sepsis and inhibits inflammatory responses in RAW264.7 cells".JOURNAL OF ETHNOPHARMACOLOGY 236(2019):63-69.
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