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Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL‐4Rα‐Jak1‐STAT6 and Jagged1/Jagged2‐Notch1/Notch2 pathways in asthmatic mice
Bin Lin Chen1,2; Yan Qiu Chen3; Bai Hui Ma1,2; Si Fei Yu4; Li Yue Li5,6; Qing Xiang Zeng3; Yu Tao Zhou5,6; Yin Fan Wu1,2; Wen long Liu3; Jian Bo Wan7; Yan Yang1,2; Chun Wei Li5,6
2018-11
Source PublicationCLINICAL AND EXPERIMENTAL ALLERGY
ISSN0954-7894
Volume48Issue:11Pages:1494-1508
Abstract

Background

Curcumin (Cur), derived from Curcuma species, exhibits anti‐inflammatory, antioxidant, and anticancer effects. Although Cur has some beneficial effects on asthma, its clinical application is limited by its low bioavailability. Tetrahydrocurcumin (THC), the major active metabolite of Cur, has multiple biological functions, similarly to Cur, and importantly, it showed enhanced bioavailability in tissues and plasma. However, the effect of THC on asthma has not been reported.

Objective

The current study sought to investigate the efficacy of dietary THC on allergic asthma compared to that of Cur in an animal model.

Methods

The anti‐inflammatory effects of Cur and THC were evaluated in an ovalbumin‐induced asthmatic mouse model. The nasal symptoms, pathological alterations of the lung tissues, oxidants and antioxidants, cytokine production, T cell subsets, and Th2‐related signalling pathway activity were assessed.

Results

Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper‐production), oxidative stress (malondialdehyde), cytokine production (IL‐13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL‐4Rα‐Jak1‐STAT6 and Jagged1/Jagged2‐Notch1/Notch2 axis) activity. THC was more effective than Cur in suppressing tissue eosinophilia, mucus production, and IL‐4Rα/Jak1/STAT6 pathway activity. Furthermore, only THC inhibited peripheral eosinophil levels, Th2 cytokines (IL‐4 and IL‐5), and Th2 cell subsets and enhanced an antioxidant enzyme (glutathione).

Conclusion and Clinical Relevance

The above results demonstrated for the first time that THC was superior to Cur in modulating allergic asthmatic phenotypes, especially attenuating the Th2 response. THC might be a potentially effective agent for asthma treatment.

Other Abstract
 
 
KeywordAirway Inflammation Asthma Dietary Factor Tetrahydrocurcumin Th2 Response
DOI10.1111/cea.13258
Indexed BySCI
Language英语
WOS Research AreaAllergy ; Immunology
WOS SubjectAllergy ; Immunology
WOS IDWOS:000449542500013
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Citation statistics
Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Public Health (Shenzhen), SunYat-sen University, Guangzhou, China
2.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University(Guangzhou Campus), Guangzhou, China
3.Department of Otolaryngology, Guangzhou Women and Children Medical Centre,Guangzhou, China
4.Institute of Immunology, Zhongshan School of Medicine, Sun Yat-sen University,Guangzhou, China
5.Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University,Guangzhou, China
6.Guangzhou Key Laboratory of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University,Guangzhou, China
7.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Macau, China
Recommended Citation
GB/T 7714
Bin Lin Chen,Yan Qiu Chen,Bai Hui Ma,et al. Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL‐4Rα‐Jak1‐STAT6 and Jagged1/Jagged2‐Notch1/Notch2 pathways in asthmatic mice[J]. CLINICAL AND EXPERIMENTAL ALLERGY,2018,48(11):1494-1508.
APA Bin Lin Chen.,Yan Qiu Chen.,Bai Hui Ma.,Si Fei Yu.,Li Yue Li.,...&Chun Wei Li.(2018).Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL‐4Rα‐Jak1‐STAT6 and Jagged1/Jagged2‐Notch1/Notch2 pathways in asthmatic mice.CLINICAL AND EXPERIMENTAL ALLERGY,48(11),1494-1508.
MLA Bin Lin Chen,et al."Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL‐4Rα‐Jak1‐STAT6 and Jagged1/Jagged2‐Notch1/Notch2 pathways in asthmatic mice".CLINICAL AND EXPERIMENTAL ALLERGY 48.11(2018):1494-1508.
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