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Metabonomics Study on the Hepatoprotective Effect of Panax notoginseng Leaf Saponins Using UPLC/Q-TOF-MS Analysis
Fang Liu1; Meng Wang2; Yang Wang2; Yiwei Cao2; Zhaolin Sun2; Mingcang Chen1; Xiaoting Tian1; Jianbo Wan2; Chenggang Huang1
2019
Source PublicationAMERICAN JOURNAL OF CHINESE MEDICINE
ISSN0192-415X
Volume47Issue:3Pages:559-575
Abstract

Alcohol liver disease is a major public health problem associated with lifestyle. Our recent study demonstrated that the roots of Panax notoginseng saponins (PNS) exert hepatoprotective effects against alcohol consumption. Considering that the leaves of Panax notoginseng saponins (LPNS) have similar chemical ingredients with PNS, increased attention should be given to the hepatoprotective effects of LPNS. In this study, a metabonomic approach based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) was developed to evaluate the hepatoprotective effect of LPNS on alcoholic fatty liver and elucidate the interaction mechanisms. Results showed that the ethanol-induced metabolic perturbations were restored after treatment with LPNS. Furthermore, 12 potential biomarkers (11 upregulated and 1 downregulated) were identified by V-plot and orthogonal partial least square discriminant analysis. Changes in the levels of these metabolites indicated that glycerophospholipid and fatty acid metabolism were disturbed in alcoholic fatty liver mouse. Our findings demonstrated that the UHPLC–QTOF/MS-based metabonomic method may provide a useful means

KeywordAlcoholic Fatty Liver Lpns Uhplc-qtof/ms Metabonomics
DOI10.1142/S0192415X19500290
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000468960700005
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Shanghai Research Center for Modernization of Traditional Chinese Medicine Shanghai Institute of Material Medica Chinese Academy of Science, Shanghai Zhangjiang Hitech Park Shanghai 201203, P. R. China
2.State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences, University of Macau Avenida da Universidade, Taipa Macau 999078, P. R. China
Recommended Citation
GB/T 7714
Fang Liu,Meng Wang,Yang Wang,et al. Metabonomics Study on the Hepatoprotective Effect of Panax notoginseng Leaf Saponins Using UPLC/Q-TOF-MS Analysis[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2019,47(3):559-575.
APA Fang Liu.,Meng Wang.,Yang Wang.,Yiwei Cao.,Zhaolin Sun.,...&Chenggang Huang.(2019).Metabonomics Study on the Hepatoprotective Effect of Panax notoginseng Leaf Saponins Using UPLC/Q-TOF-MS Analysis.AMERICAN JOURNAL OF CHINESE MEDICINE,47(3),559-575.
MLA Fang Liu,et al."Metabonomics Study on the Hepatoprotective Effect of Panax notoginseng Leaf Saponins Using UPLC/Q-TOF-MS Analysis".AMERICAN JOURNAL OF CHINESE MEDICINE 47.3(2019):559-575.
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