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Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future
Khan, Harron; Jawad, Mohammad; Kamal, Mohammad Amjad; Baldi, Alessandra; Xiao, Jianbo; Nabavi, Seyed Mohammad; Daglia, Maria
2018-09
Conference NameFOOD AND CHEMICAL TOXICOLOGY
Volume119
Pages355-367
Publication PlaceTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
PublisherPERGAMON-ELSEVIER SCIENCE LTD
AbstractPlatelets are involved in hemostasis, inflammation, and thrombosis processes. Following a vascular damage, the endothelium releases protein factors, allowing the adhesion of subendothelium to platelets. Then platelets are activated, leading to the secretion of biologically-active ligands including thromboxane A2, adenosine diphosphate and serotonin. Aspirin, clopidogrel and warfarin are the most common drugs used to meet the challenges of platelet aggregation. However, these agents face issues with aspirin resistance and bleeding. New therapeutically effective and safe agents are therefore strongly needed, and natural substances could be ideal candidates. Flavonoids, a chemically diverse group of polyphenols, might be important in this regard. Consumption of flavonoids is responsible for several health-promoting properties. A number of flavonoids have shown outstanding preclinical antiplatelet effects through various mechanisms. Flavonoids could provide an ideal approach as templates for new, clinically-effective and safe antiplatelet agents due to their inherent safety and multiple useful pharmacological hits. This review aims to report data from literature regarding flavonoids with antiplatelet activity, with a particular focus on possible mechanisms of action, pharmacokinetic profiles and overall safety, thus providing a strong rationale for the design of selective and well-directed antiplatelet agents of natural origin.
KeywordAntiplatelet Preclinical studies Structure-activity relationship (SAR) studies Pharmacokinetic parameters Safety profile
DOI10.1016/j.fct.2018.02.014
URLView the original
Indexed BySCI ; CPCI
Language英语
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000443664200042
The Source to ArticleWOS
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Khan, Harron,Jawad, Mohammad,Kamal, Mohammad Amjad,et al. Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future[C]. THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND:PERGAMON-ELSEVIER SCIENCE LTD,2018:355-367.
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