UM  > 中華醫藥研究院
Development of functional dendrisomes based on a single molecule of polyesterbenzylether dendrimer and their application in cancer stem cell therapy
Li-Min Mu1; Lei Liu1; Rui Liu1; Jia-Lun Duan1; Shuang Ma1; Xue-Qi Li1; Yi-Nuo Cui1; Zhan-Bo Su1; Xiao Zhang1; Jian-Xing Hu1; Ying Xie1; Ying Zheng2; Wan-Liang Lu1
2019-07-05
Source PublicationNPG ASIA MATERIALS
ISSN1884-4049
Volume11
Abstract

The differentiation therapy of breast cancer stem cells (CSCs) represents a significant strategy to treat cancer, but inefficient delivery to CSCs hinders the efficacy of differentiation agents. In this work, we report a type of functional dendrisomes constructed by the synthesized amphiphilic dendrimers, which enhance cellular uptake by breast CSCs, differentiate breast CSCs by carrying all-trans retinoic acid (ATRA), and increase the anticancer efficacy by carrying ATRA and docetaxel (DTX) in vitro and in breast cancer-bearing mice. The study further reveals the mechanism of cellular uptake by breast CSCs and uncovers the differentiation mechanism by analyzing relevant signal molecules, transcription factors, and cell cycle-associated signaling pathways during differentiation therapy in breast CSCs. Hence, this study offers a novel type of functional dendrisomes for differentiation therapy of breast CSCs and has significant clinical implications.

DOIhttps://doi.org/10.1038/s41427-019-0134-x
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000476564400002
Fulltext Access
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWan-Liang Lu
Affiliation1.State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Molecular Pharmaceutics and New Drug System, School of Pharmaceutical Sciences, Peking University, Beijing, China
2.Institute of Chinese Medical Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Li-Min Mu,Lei Liu,Rui Liu,et al. Development of functional dendrisomes based on a single molecule of polyesterbenzylether dendrimer and their application in cancer stem cell therapy[J]. NPG ASIA MATERIALS,2019,11.
APA Li-Min Mu.,Lei Liu.,Rui Liu.,Jia-Lun Duan.,Shuang Ma.,...&Wan-Liang Lu.(2019).Development of functional dendrisomes based on a single molecule of polyesterbenzylether dendrimer and their application in cancer stem cell therapy.NPG ASIA MATERIALS,11.
MLA Li-Min Mu,et al."Development of functional dendrisomes based on a single molecule of polyesterbenzylether dendrimer and their application in cancer stem cell therapy".NPG ASIA MATERIALS 11(2019).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li-Min Mu]'s Articles
[Lei Liu]'s Articles
[Rui Liu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li-Min Mu]'s Articles
[Lei Liu]'s Articles
[Rui Liu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li-Min Mu]'s Articles
[Lei Liu]'s Articles
[Rui Liu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.