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Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity
Shikang Meng1; Lin Sun2; Lun Wang1; Zibei Lin1; Zeyu Liu1; Long Xi1; Zhenping Wang3; Ying Zheng1
2019-10
Source PublicationColloids and Surfaces B: Biointerfaces
ISSN0927-7765
Volume182
Abstract

Psoriasis is a severe disfiguring skin disease affecting approximately 3% of people worldwide and negatively affecting their daily lives. The pathogenesis of psoriasis is complicated, and typical therapeutic strategies for psoriasis mainly focus on anti-inflammation. Considering the side effects, withdrawal rebound, high cost, and many other disadvantages of existing treatments, we developed a new topical therapeutic formulation consisting of niosomes loaded with celastrol, a triterpenoid extracted from Tripterygium. Celastrol niosomes were prepared by the thin film hydration method and probe sonication. The niosomes were composed of Span 20, Span 60, and cholesterol at a weight ratio of 3:1:1. The particle size of the niosomes was approximately 147 nm, with yield of up to 90%. Celastrol niosomes showed improved in vitro permeation ability compared to the raw drug. In our in vivo study, celastrol niosomes effectively alleviated erythema and scaling on the dorsal skin of psoriasis mouse models. Spleen weight and the levels of cytokines, including IL-22, IL-23, and IL-17, decreased after the treatment, indicating the high therapeutic potential of this formulation for psoriasis. In conclusion, encapsulation of celastrol by niosomes increased the water-solubility and permeation of celastrol into the skin, significantly improving its anti-psoriasis activity in mice.

KeywordCelastrol Niosomes Psoriasis Topical Permeation
DOIhttps://doi.org/10.1016/j.colsurfb.2019.110352
Indexed BySCI
Language英语
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, bioMaterials
WOS IDWOS:000489190200014
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYing Zheng
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Zhuhai Campus of Zunyi Medical University, Department of Pharmaceutical Sciences, China
3.Department of Dermatology, School of Medicine, University of California, San Diego, La Jolla, CA, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Shikang Meng,Lin Sun,Lun Wang,et al. Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity[J]. Colloids and Surfaces B: Biointerfaces,2019,182.
APA Shikang Meng.,Lin Sun.,Lun Wang.,Zibei Lin.,Zeyu Liu.,...&Ying Zheng.(2019).Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.Colloids and Surfaces B: Biointerfaces,182.
MLA Shikang Meng,et al."Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity".Colloids and Surfaces B: Biointerfaces 182(2019).
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