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An Eco- and User-Friendly Herbicide
Xiangjun Zhang1; Qiaoxian Huang1; Zhe-Ze Zhao2; Xiaoqiu Xu3; Shengke Li1; Hang Yin1; Lanlan Li3; Jianxiang Zhang3; Ruibing Wang1
2019-07
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume67Issue:28Pages:7783-7792
Abstract

The increasing use of pesticides in agriculture and gardening has caused severe deterioration to both theecosystem and the health of users (human beings), so there is an urgent need for eco- and user-friendly pesticides. Among avariety of herbicides, paraquat (PQ), frequently used as an effective herbicidal agent worldwide, is well-known for its serioustoxicity that has killed, and harmed, thousands of people and countless wildlife such asfish. Herein, we present a facilesupramolecular formulation of PQ@cucurbit[7]uril (PQ@CB[7]), prepared by simply mixing PQ with equivalent (molar)CB[7] in water. With addition of CB[7], PQ’s cellular uptake was dramatically inhibited. The reactive oxygen species (ROS)generation and the associated apoptosis otherwise induced by PQ in cellular models were both reduced, resulting in increasedcellular viability. In a wildtype zebrafish model that is a typical fragile wildlife species in the ecosystem, the supramolecularformulation exhibited significantly reduced hepatotoxicity and increased survival rate, in comparison with those of thefishexposed to free PQ. In a mouse model that is clinically relevant to human being, the administration of PQ@CB[7] significantlyalleviated major organ injuries and unusual hematological parameters that were otherwise induced by free PQ, resulting in asignificantly increased survival rate. Meanwhile, this formulation maintained effective herbicidal activity that was equivalent tothat of free PQ. Taken together, this facile supramolecular PQ formulation is providing not only an extremely rare example of aneco- and user-friendly herbicide that has been desired for decades but also a practical solution for green agriculture.

KeywordFriendly Herbicide Paraquat Cucurbit[7]Uril Upramolecular Chemistry
DOI10.1021/acs.jafc.9b00764
Indexed BySCI
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000476686200001
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa,Macau 999078, China
2.School of Life Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong China
3.Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xiangjun Zhang,Qiaoxian Huang,Zhe-Ze Zhao,et al. An Eco- and User-Friendly Herbicide[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(28):7783-7792.
APA Xiangjun Zhang.,Qiaoxian Huang.,Zhe-Ze Zhao.,Xiaoqiu Xu.,Shengke Li.,...&Ruibing Wang.(2019).An Eco- and User-Friendly Herbicide.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(28),7783-7792.
MLA Xiangjun Zhang,et al."An Eco- and User-Friendly Herbicide".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.28(2019):7783-7792.
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