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Nano-carriers for delivery and targeting of active ingredients of Chinese medicine for hepatocellular carcinoma therapy
Meiwan Chen1; Xingzhi Zhou1; Ruie Chen1; Junlin Wang1; Richard D. Ye1; Yitao Wang1; Chuanbin Wu2; Ram I. Mahato3
2019-05
Source PublicationMATERIALS TODAY
ISSN1369-7021
Volume25Pages:66-87
Abstract

Active ingredients from Chinese medicine (AIFCM) are emerging as a class of anticancer agents for treating hepatocellular carcinoma (HCC). AIFCM have unique advantages over traditional chemotherapeutic drugs, such as their multi-target, multi-level, and coordinated intervention effects against HCC. Recent researches demonstrated their potentials in inhibiting HCC initiation, cell proliferation, angiogenesis, and metastasis. With the advantages of nano-carriers including better bioavailability, significant features of passive or active targeting and stimulus-responsive drug release. Formulation of AIFCM and nano-carriers shows great potential in promoting anti-HCC therapeutic development. Here, we critically assess nano-carriers for delivery and targeting of AIFCM for HCC therapy. First, we offer an overview of major pathogenic factors to induce HCC, including virus infection, alcoholic liver disease, mycotoxin, obesity, and type 2 diabetes. Second, the mechanisms of AIFCM for HCC therapy comprising gene regulation and transduction of different molecular pathways are discussed. Third, significant achievements of AIFCM-encapsulated nano-carriers and AIFCM-modified nano-carriers against HCC are presented. Finally, we provide concluding remarks and future perspectives of AIFCM for HCC therapy, hoping to offer some insight on how to improve AIFCM-based HCC therapy.

DOIhttps://doi.org/10.1016/j.mattod.2018.10.040
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000467714400019
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMeiwan Chen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
3.Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Meiwan Chen,Xingzhi Zhou,Ruie Chen,et al. Nano-carriers for delivery and targeting of active ingredients of Chinese medicine for hepatocellular carcinoma therapy[J]. MATERIALS TODAY,2019,25:66-87.
APA Meiwan Chen.,Xingzhi Zhou.,Ruie Chen.,Junlin Wang.,Richard D. Ye.,...&Ram I. Mahato.(2019).Nano-carriers for delivery and targeting of active ingredients of Chinese medicine for hepatocellular carcinoma therapy.MATERIALS TODAY,25,66-87.
MLA Meiwan Chen,et al."Nano-carriers for delivery and targeting of active ingredients of Chinese medicine for hepatocellular carcinoma therapy".MATERIALS TODAY 25(2019):66-87.
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