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Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease
Caifang Gao1; Lijuan Liu1,2,3; Yangyang Zhou1; Zhaoxiang Bian4; Shengpeng Wang1,5; Yitao Wang1
2019-07-17
Source PublicationChinese Medicine
ISSN1749-8546
Volume14
Abstract

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that comprises ulcerative colitis (UC) and Crohn’s disease (CD). IBD involves the ileum, rectum, and colon, and common clinical manifestations of IBD are diarrhea, abdominal pain, and even bloody stools. Currently, non-steroidal anti-inflammatory drugs, glucocorticoids, and immunosuppressive agents are used for the treatment of IBD, while their clinical application is severely limited due to unwanted side effects. Chinese medicine (CM) is appealing more and more attention and investigation for the treatment of IBD owing to the potent anti-inflammation pharmacological efficacy and high acceptance by patients. In recent years, novel drug delivery systems are introduced apace to encapsulate CM and many CM-derived active constituents in order to improve solubility, stability and targeting ability. In this review, advanced drug delivery systems developed in the past and present to deliver CM for the treatment of IBD are summarized and future directions are discussed.

KeywordInfammatory Bowel Disease Chinese Medicine Drug Delivery System Ulcerative Colitis
DOIhttps://doi.org/10.1186/s13020-019-0245-x
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000471901100001
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorShengpeng Wang; Yitao Wang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao, SAR, China
2.PU-UM Innovative Institute of Chinese Medical Sciences, Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd, Hengqin New Area, Zhuhai, China
3.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
4.School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, SAR, China
5.Leiden University European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University, Leiden, The Netherlands
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Caifang Gao,Lijuan Liu,Yangyang Zhou,et al. Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease[J]. Chinese Medicine,2019,14.
APA Caifang Gao,Lijuan Liu,Yangyang Zhou,Zhaoxiang Bian,Shengpeng Wang,&Yitao Wang.(2019).Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease.Chinese Medicine,14.
MLA Caifang Gao,et al."Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease".Chinese Medicine 14(2019).
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