UM  > 中華醫藥研究院
Investigating molecular interactions of high-loaded glipizide-HPMCAS microparticles by integrated experimental and modeling techniques
Qiang Li1; Qianqian Zhao2; Qiufang Jing1; Xiaosi Ma1; Ning Chen1; Guobin Ren1; Defang Ouyang2; Fuzheng Ren1
2019-02-05
Source PublicationEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN0928-0987
Volume131Pages:127-135
Abstract

Molecular interactions between drug and polymeric carriers are believed to be the key for high drug loading and better physical stability of micro-particles. However, molecular interactions between drug and polymer are still difficult to investigate using only experimental tools. In this study, high-loaded glipizide (GLP)/hydroxypropyl methylcellulose acetate succinate (HPMCAS) (1/1 w/w) micro-particles were prepared using an in situ pHdependent solubility method. Molecular interactions within the micro-particles were investigated by integrated experimental and modeling techniques. The dissolution rate of GLP/HPMCAS micro-particles was significantly better than those of solid dispersions and physical mixtures. Scanning electron microscopy images showed that the polymer inhibited GLP recrystallization. Experimental (FTIR spectroscopy, differential scanning calorimetry, powder X-ray diffraction and nuclear magnetic resonance spectroscopy) and molecular dynamics simulation revealed that hydrogen-bonding was the key to the properties of the micro-particles. Our research developed high drug-loading GLP/HPMCAS micro-particles and investigated the interactions between drug and polymer at the molecular level. This integrated approach could be practical methodology for future formulation design.
 

KeywordGlipizide Hydroxypropyl Methylcellulose Acetate Succinate (Hpmcas) Molecular Interaction Molecular Dynamics Simulation
DOI10.1016/j.ejps.2019.02.005
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000460399800014
PublisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDefang Ouyang; Fuzheng Ren
Affiliation1.Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Qiang Li,Qianqian Zhao,Qiufang Jing,et al. Investigating molecular interactions of high-loaded glipizide-HPMCAS microparticles by integrated experimental and modeling techniques[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2019,131:127-135.
APA Qiang Li.,Qianqian Zhao.,Qiufang Jing.,Xiaosi Ma.,Ning Chen.,...&Fuzheng Ren.(2019).Investigating molecular interactions of high-loaded glipizide-HPMCAS microparticles by integrated experimental and modeling techniques.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,131,127-135.
MLA Qiang Li,et al."Investigating molecular interactions of high-loaded glipizide-HPMCAS microparticles by integrated experimental and modeling techniques".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 131(2019):127-135.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Qiang Li]'s Articles
[Qianqian Zhao]'s Articles
[Qiufang Jing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qiang Li]'s Articles
[Qianqian Zhao]'s Articles
[Qiufang Jing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qiang Li]'s Articles
[Qianqian Zhao]'s Articles
[Qiufang Jing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.