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Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects
Yan He1; Hongfei Liu2; Wangqing Bian1; Yue Liu3; Xinyang Liu4; Shijing Ma1; Xi Zheng1,3; Zhiyun Du1; Kun Zhang1,2; Defang Ouyang4
2019-09-01
Source PublicationPHARMACEUTICS
ISSN1999-4923
Volume11Issue:9
Abstract

The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions. In this study, a series of amorphous solid dispersions (ASD) of Curcumin (Cur) were prepared with different polymers by the solvent evaporation method. With the carrier polyvinylpyrrolidone (PVP), the amorphous solid dispersion system exhibits a better solubility and stability than that with poloxamers and HP-β-CD due to the strong drug-polymer interaction. The drug/polymer interaction and their binding sites were investigated by combined experimental (XRD, DSC, FTIR, SEM, Raman, and 1H-NMR) and molecular dynamics simulation techniques. The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1β, IL-6, VEGF, MIP-2, and TNF-α) compared to the raw Curcumin. The integration of experimental and modeling techniques is a powerful tool for the rational design of formulation development.

KeywordCurcumin Polyvinylpyrrolidone (Pvp) Solid Dispersions Molecular Modeling Drug-polymer Interactions
DOI10.3390/pharmaceutics11090442
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000489151700029
PublisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorKun Zhang; Defang Ouyang
Affiliation1.Allan H. Conney Laboratory for Anticancer Research, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China
2.School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
3.Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yan He,Hongfei Liu,Wangqing Bian,et al. Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects[J]. PHARMACEUTICS,2019,11(9).
APA Yan He.,Hongfei Liu.,Wangqing Bian.,Yue Liu.,Xinyang Liu.,...&Defang Ouyang.(2019).Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects.PHARMACEUTICS,11(9).
MLA Yan He,et al."Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects".PHARMACEUTICS 11.9(2019).
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