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Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies
Ma, DL1; Wu, C1; Cheng, SS2; Lee, FW3; Han, QB4; Leung, CH2
2019
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume20Issue:2
AbstractPlatinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.
KeywordCancer Therapy Cytotoxicity Natural Product Transition Metal Complex
DOI10.3390/ijms20020341
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000459746500109
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong 999077, Peoples R China
2.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
3.Hong Kong Baptist Univ, Sch Continuing Educ, Coll Int Educ, Shek Mun, Hong Kong 999077, Peoples R China
4.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong 999077, Peoples R China
Recommended Citation
GB/T 7714
Ma, DL,Wu, C,Cheng, SS,et al. Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(2).
APA Ma, DL,Wu, C,Cheng, SS,Lee, FW,Han, QB,&Leung, CH.(2019).Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(2).
MLA Ma, DL,et al."Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.2(2019).
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