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Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells
Wang, WH1; Lu, LH2; Wu, KJ3; Liu, JS4; Leung, CH3; Wong, CY5; Ma, DL1
2019
Source PublicationSENSORS AND ACTUATORS B-CHEMICAL
ISSN0925-4005
Volume288Pages:392-398
AbstractPeriodate (IO4-) is a widely used reagent in organic synthesis and for biomolecular modification. However, highly sensitive fluorescence detection methods for IO4- are lacking. In this work, we designed and synthesized iridium(III) complexes for the detection of IO4- by the incorporation of a methylthio group to serve as a luminescence trigger. The results showed that complex 1 could detect IO4- in a sensitive and selective manner with a detection limit of 0.077 mu M, rendering it more sensitive than reported fluorescence methods. Meanwhile, its inherently long emission lifetime enables its luminescence response to IO4- to be detected even in the presence of organic dyes by the use of time-resolved emission spectroscopy (TRES). This probe was further demonstrated to detect IO4- in living cells. To our knowledge, complex 1 is first long-lived iridium(III)-based probe for the sensitive detection of IO4-, and is also one of few existing imaging probes for IO4-.
KeywordTime-resolved Emission Spectroscopy Periodate Iridium(Iii) Complex Luminescence Probe Cell Imaging Long Emission Lifetime
DOI10.1016/j.snb.2019.03.019
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Instruments & Instrumentation ; Electrochemistry
WOS SubjectChemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS IDWOS:000462468000050
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa, DL
Affiliation1.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
2.Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China
3.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
4.Anhui Normal Univ, Coll Chem & Mat Sci, Anhui Key Lab Chemo Biosensin, Key Lab Funct Mol Solids,Minist Educ,Anhui Lab Mo, Wuhu, Peoples R China
5.City Univ Hong Kong, Dept Chem, Tat Chee Ave, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, WH,Lu, LH,Wu, KJ,et al. Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells[J]. SENSORS AND ACTUATORS B-CHEMICAL,2019,288:392-398.
APA Wang, WH.,Lu, LH.,Wu, KJ.,Liu, JS.,Leung, CH.,...&Ma, DL.(2019).Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells.SENSORS AND ACTUATORS B-CHEMICAL,288,392-398.
MLA Wang, WH,et al."Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells".SENSORS AND ACTUATORS B-CHEMICAL 288(2019):392-398.
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