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An iridium(III) complex/G-quadruplex ensemble for detection of ochratoxin A based on long-lifetime luminescent
Zhang, JT1; Kang, TS1; Wong, SY2; Pei, RJ3; Ma, DL2; Leung, CH1
2019
Source PublicationANALYTICAL BIOCHEMISTRY
ISSN0003-2697
Volume580Pages:49-55
AbstractA G-quadruplex-based platform has been developed for the time-resolved monitoring of ochratoxin A (OTA). The simple platform displays good sensitivity for OTA with a detection limit of 40 nM via steady-state emission spectroscopy. Notably, the platform showed a detection limit of 10.8 nM via time-resolved emission spectroscopy (TRES), which is about 4 times more sensitive than steady-state mode. Moreover, the probe showed excellent selectivity for OTA over other mycotoxins. Furthermore, OTA was successfully detected in actual herbal plant extracts samples. Our platform is the first to detect OTA using TRES to distinguish between the target signals versus the auto-fluorescence of real samples. This platform shows improved detection speed, accuracy and sensitivity with simple operation, low cost, and no requirement for complicated pre-processing.
KeywordOta Herbal Plant Extracts Tres G-quadruplex
DOI10.1016/j.ab.2019.06.005
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical
WOS IDWOS:000476576000007
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa, DL
Affiliation1.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China.
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong 999077, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Nanobio Interface, Div Nanobiomed, Suzhou Inst Nanotech & Nanobion, Suzhou 215123, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, JT,Kang, TS,Wong, SY,et al. An iridium(III) complex/G-quadruplex ensemble for detection of ochratoxin A based on long-lifetime luminescent[J]. ANALYTICAL BIOCHEMISTRY,2019,580:49-55.
APA Zhang, JT,Kang, TS,Wong, SY,Pei, RJ,Ma, DL,&Leung, CH.(2019).An iridium(III) complex/G-quadruplex ensemble for detection of ochratoxin A based on long-lifetime luminescent.ANALYTICAL BIOCHEMISTRY,580,49-55.
MLA Zhang, JT,et al."An iridium(III) complex/G-quadruplex ensemble for detection of ochratoxin A based on long-lifetime luminescent".ANALYTICAL BIOCHEMISTRY 580(2019):49-55.
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