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Cycloartane triterpenoids from Actaea vaginata with anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages
Zhu-JunFang1; TianZhang2; Shi-XinChen1; Yan-LanWang1; Chang-XinZhou1; Jian-XiaMo1; Yong-JiangWu1; You-KaiXu3; Li-GenLin2; Li-SheGan1,4
2019
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume160
Abstract

Five undescribed cycloartane triterpenoids, including two cycloartane trinor-triterpenoids, were isolated from a 70% ethanol extract of the whole plant of Actaea vaginata (Ranunculaceae), together with thirteen known cycloartane triterpenoids. Their structures were determined by spectroscopic techniques and quantum chemical calculations for intramolecular noncovalent interactions with reduced density gradient method. All compounds were evaluated for their anti-inflammatory effects by a lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production model in RAW264.7 macrophage cells, and some showed potent inhibitory effects with IC50 values ranging from 5.0 to 24.4 μM. Further mechanism studies showed that one compound dose-dependently suppressed LPS-induced NO production and pro-inflammatory cytokines secretion, and decreased the expression of iNOS, through inhibiting NF-κB activation.

KeywordInducible No Synthase Actaea Vaginata (Ranunculaceae) Cycloartane Trinortriterpenoids Reduced Density Gradient Nf-kappa b Pathway
DOI10.1016/j.phytochem.2019.01.003
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000462104000001
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi-SheGan
Affiliation1.College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, PR China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, PR China
3.Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, PR China
4.Hangzhou Institute of Innovative Medicine, Zhejiang University, 291 Fucheng Road, Hangzhou 310018, PR China
Recommended Citation
GB/T 7714
Zhu-JunFang,TianZhang,Shi-XinChen,et al. Cycloartane triterpenoids from Actaea vaginata with anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages[J]. PHYTOCHEMISTRY,2019,160.
APA Zhu-JunFang.,TianZhang.,Shi-XinChen.,Yan-LanWang.,Chang-XinZhou.,...&Li-SheGan.(2019).Cycloartane triterpenoids from Actaea vaginata with anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages.PHYTOCHEMISTRY,160.
MLA Zhu-JunFang,et al."Cycloartane triterpenoids from Actaea vaginata with anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages".PHYTOCHEMISTRY 160(2019).
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