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Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology
Zhi Xin Li1; Guan Ding Zhao1; Wei Xiong1; Ke Gang Linghu1; Qiu Shuo Ma1; Wai San Cheang1; Hua Yu1,2,3,4; Yitao Wang1,5
2019-03-27
Source PublicationCHINESE MEDICINE
ISSN1749-8546
Volume14
Abstract

Background: Water extract (WAE) and ultrafne powder (UFP) are two types of commonly used supplements in preparing various pharmaceutical products and functional foods. However, the correlations of the chemical compositions with the traditional functions between WAE and the herb itself, as well as the potential problems of safety for UFP have been more and more concerned by many doctors and customers. Methods: In this study, a new whole ingredients extract of Astragalus (WIE) was prepared using the gradient solvent extraction method. The chemical compositions of WIE and WAE were comparatively analysed using spectrophotometric and chromatographic approaches. In addition, the in vivo immunomodulatory efect of WIE, WAE and UFP of Astragalus were comprehensively compared in cyclophosphamide (Cy)-induced immunosuppressive mice. Results: The compositions and contents of main active ingredients (polysaccharides, saponins and favonoids) in WIE were determined to be more abundant than those in WAE. In Cy-induced immunosuppressive mice, oral administered with low dosage of WIE (equalled to 1.0 g herb/kg/day) for 18 consecutive days signifcantly improved the immune-related responses (body weight, number of peripheral white blood cells, thymus and spleen indexes, splenocyte proliferations, natural killer cell activity, splenic lymphocyte subset, and serum levels of immunoglobulins G and M). The potency of three Astragalus preparations on immunomodulation was observed to be WIE≥UFP>WAE. Conclusions: WIE maximally retained the chemical integrity of astragalus, and presented better therapeutic efectiveness than UFP and WAE. It can be further developed as new strategy for reasonable use of medicinal/edible herbderived supplement (extract) for pharmaceutical and healthcare applications. Keywords: Whole ingredients extract, Chemical integrity, Immunomodulation, Astragali Radix

KeywordWhole Ingredients Extract Chemical Integrity Immunomodulation Astragali Radix
DOI10.1186/s13020-019-0234-0
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000462905200001
PublisherBMC, CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYitao Wang
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China
2.HKBU Shenzhen Research Center, Shenzhen, Guangdong, China
3.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
4.Institute of Chinese Medical Sciences, University of Macau, Room 8008, Building N22, Avenida da Universidade, Taipa, Macao SAR, China
5.Institute of Chinese Medical Sciences, University of Macau, Room 1050, Building N22, Avenida da Universidade, Taipa, Macao SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhi Xin Li,Guan Ding Zhao,Wei Xiong,et al. Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology[J]. CHINESE MEDICINE,2019,14.
APA Zhi Xin Li.,Guan Ding Zhao.,Wei Xiong.,Ke Gang Linghu.,Qiu Shuo Ma.,...&Yitao Wang.(2019).Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology.CHINESE MEDICINE,14.
MLA Zhi Xin Li,et al."Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology".CHINESE MEDICINE 14(2019).
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