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Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach
Cao, Hui; Liu, Xiaojuan; Ulrih, Natasa Poklar; Sengupta, Pradeep K.; Xiao, Jianbo
2019-01
Conference NameFOOD CHEMISTRY
Volume270
Pages257-263
Publication PlaceTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
PublisherELSEVIER SCI LTD
AbstractHerein, the protein binding rates of structurally different flavonoids to human serum albumin (HSA) were elucidated by applying the high performance affinity chromatography (HPAC). The flavonoids with hydroxyl groups on ring A showed a higher protein binding rate compared with those that there was no hydroxyl on ring A. However, the hydroxylation of ring B lowered the protein binding rate. It was also found that an additional methoxy group in flavone ring A would decrease the protein binding rate. Nevertheless, the methoxy group in flavanone ring A (position 6) and isoflavone ring B (position 4') increased the protein binding rate. Methoxy group at other positions of flavonoids slightly enhanced or no significantly affected the binding rates on human serum albumin. Hydrogenation of C2=C3 double bond of flavonoids decreased the protein binding rate and had the same effect as glycosylation which decrease the protein binding rate by 5%-25%.
KeywordFlavonoids Structure-protein binding relationship Protein binding rate HSA
DOI10.1016/j.foodchem.2018.07.111
URLView the original
Indexed BySCI ; CPCI
Language英语
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000443253200032
The Source to ArticleWOS
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionUniversity of Macau
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Cao, Hui,Liu, Xiaojuan,Ulrih, Natasa Poklar,et al. Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach[C]. THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND:ELSEVIER SCI LTD,2019:257-263.
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