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Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach
Cao, Hui1,2; Liu, Xiaojuan2; Ulrih, Natasa Poklar3; Sengupta, Pradeep K.4; Xiao, Jianbo2
2019-01
Conference Name3rd International Symposium on Phytochemicals in Medicine and Food (ISPMF)
Source PublicationFOOD CHEMISTRY
Volume270
Pages257-263
Conference DateAUG 25-30, 2018
Conference PlaceKunming, PEOPLES R CHINA
Publication PlaceTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
PublisherELSEVIER SCI LTD
Abstract

Herein, the protein binding rates of structurally different flavonoids to human serum albumin (HSA) were elucidated by applying the high performance affinity chromatography (HPAC). The flavonoids with hydroxyl groups on ring A showed a higher protein binding rate compared with those that there was no hydroxyl on ring A. However, the hydroxylation of ring B lowered the protein binding rate. It was also found that an additional methoxy group in flavone ring A would decrease the protein binding rate. Nevertheless, the methoxy group in flavanone ring A (position 6) and isoflavone ring B (position 4') increased the protein binding rate. Methoxy group at other positions of flavonoids slightly enhanced or no significantly affected the binding rates on human serum albumin. Hydrogenation of C2=C3 double bond of flavonoids decreased the protein binding rate and had the same effect as glycosylation which decrease the protein binding rate by 5%-25%.

KeywordFlavonoids Structure-protein Binding Relationship Protein Binding Rate Hsa
DOI10.1016/j.foodchem.2018.07.111
URLView the original
Indexed BySCI ; CPCI
Language英语
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000443253200032
The Source to ArticleWOS
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionInstitute of Chinese Medical Sciences
Affiliation1.College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
2.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau
3.Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
4.Department of Biophysics, Molecular Biology & Bioinformatics, University of Calcutta, 92 Acharya Prafulla Chandra Road, Kolkata 700009, India
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Cao, Hui,Liu, Xiaojuan,Ulrih, Natasa Poklar,et al. Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach[C]. THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND:ELSEVIER SCI LTD,2019:257-263.
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