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No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice
Cheng-you Zheng1; Bao-jian Guo1; Wei Cai1; Wei Cui2; Shing-hung Mak3; Yu-qiang Wang1; Simon Ming-yuen Lee4; Yi-fan Han3; Zai-jun Zhang1
2016-08
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume11Issue:8Pages:1339-1346
Abstract

Rasagiline, a monoamine oxidase-B inhibitor, and bis(propyl)-cognitin (B3C), a novel dimer are reported to be neuroprotective. Herein, the synergistical neuroprotection produced by rasagiline and B3C was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice of Parkinsonism. By using neurobehavioural tests, high-performance liquid chromatography and western blot assay, we showed that B3C at 0.3 mg/kg, rasagiline at 0.02 mg/kg, as well as co-treatment with B3C and rasagiline prevented MPTP-induced behavioural abnormities, increased the concentrations of dopamine and its metabolites in the striatum, and up-regulated the expression of tyrosine hydroxylase in the substantia nigra. However, the neuroprotective effects of co-treatment were not significantly improved when compared with those of B3C or rasagiline alone. Collectively, we have demonstrated that B3C at 0.3 mg/kg and rasagline at 0.02 mg/kg could not produce synergistic neuroprotective effects.

KeywordNerve Regeneration Parkinson's Disease Bis(Propyl)-cognitin Rasagiline Monoamine Oxidase b Dopamine Multitarget Synergism Neuroprotection Neural Regeneration
DOI10.4103/1673-5374.189201
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Neurosciences & Neurology
WOS SubjectCell Biology ; Neurosciences
WOS IDWOS:000384146000032
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardiocerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong Province, China
2.School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China
3.Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hung Hom, Hong Kong Special Administrative Region, China
4.State Key Laboratory of Quality Research of Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao Special Administrative Region, China
Recommended Citation
GB/T 7714
Cheng-you Zheng,Bao-jian Guo,Wei Cai,et al. No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice[J]. NEURAL REGENERATION RESEARCH,2016,11(8):1339-1346.
APA Cheng-you Zheng.,Bao-jian Guo.,Wei Cai.,Wei Cui.,Shing-hung Mak.,...&Zai-jun Zhang.(2016).No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice.NEURAL REGENERATION RESEARCH,11(8),1339-1346.
MLA Cheng-you Zheng,et al."No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice".NEURAL REGENERATION RESEARCH 11.8(2016):1339-1346.
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