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Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease
Qiwen Liao; Yu Feng; Binrui Yang; Simon Ming-Yuen Lee
2019-01
Source PublicationDRUG DISCOVERY TODAY
ISSN1359-6446
Volume24Issue:1Pages:189-197
Abstract

Cnidaria provide the largest source of bioactive peptides for new drug development. The venoms contain enzymes, potent pore-forming toxins and neurotoxins. The neurotoxins can immobilize predators rapidly when discharged via modifying sodium-channel-gating or blocking the potassium channel during the repolarization stage. Most cnidarian neurotoxins remain conserved under the strong influence of negative selection. Neuroactive peptides targeting the central nervous system through affinity with ion channels could provide insight leading to drug treatment of neurological diseases, which arise from ion channel dysfunctions. Although marine resources offer thousands of possible peptides, only one peptide derived from Cnidaria: ShK-186, also named dalazatide, has reached the pharmaceutical market. This review focuses on neuroprotective agents derived from cnidarian neurotoxic peptides.

DOI10.1016/j.drudis.2018.08.011
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000460194900020
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Qiwen Liao,Yu Feng,Binrui Yang,et al. Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease[J]. DRUG DISCOVERY TODAY,2019,24(1):189-197.
APA Qiwen Liao,Yu Feng,Binrui Yang,&Simon Ming-Yuen Lee.(2019).Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease.DRUG DISCOVERY TODAY,24(1),189-197.
MLA Qiwen Liao,et al."Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease".DRUG DISCOVERY TODAY 24.1(2019):189-197.
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