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Hepatoprotective properties of &ITPenthorum chinense&IT Pursh against carbon tetrachloride-induced acute liver injury in mice
Wang, M1; Zhang, XJ1; Feng, RB1; Jiang, Y2; Zhang, DY2; He, CW1; Li, P1; Wan, JB1
2017
Source PublicationCHINESE MEDICINE
ISSN1749-8546
Volume12
Abstract

Background: Penthorum chinense Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been tradition ally used to treat several liver-related diseases, such as jaundice and viral hepatitis. The alms of the present study were to evaluate the probable properties of the aqueous extract of PCP on carbon tetrachloride (CCl4-induced acute liver Injury In mice.& para;& para;Methods: C57BL/6 mice were orally administered an aqueous extract of PCP (5.15 and 10.3 g/kg BW) or silymarln (100 mg/kg) once dally for 1 week prior to CCl(4 )exposure. Silymarln serves as a positive drug to validate the effectlvenes of PCP.& para;& para;Results: A single dose of CCI4 exposure caused severe acute liver Injury In mice, as evidenced by the elevated serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alanine phosphatase (ALP), and the Increased TUNEL-positlve cells In liver, which were remarkably ameliorated by the pretreatment of PCP. PCP was also found to decrease the levels of malondlaldehyde (MDA), restore the glutathione (GSH) and enhance the activities of superoxide dismutase (SOD) and catalase (CAT) In the liver. In addition, the pretreatment of PCP Inhibited the degradation of hepatic cytochrome P450 2E1 (CYP2E1), up-regulated the expression of nuclear factor erythrold 2-related factor 2 (Nrf2) and Its target proteins In CCI4-treated mice.& para;& para;Conclusion: Results Indicated that the pretreatment of PCP (10.3 g/kg BW) effectively protected against CCI4-lnduced acute liver Injury, which was comparable to efficacy of silymarln (100 mg/kg). This hepatoprotective effects might be attributed to amelioration of CCI4-lnduced oxidative stress via activating Nrf2 signaling pathway.

KeywordPenthorum Chinense Pursh Carbon Tetrachloride Nuclear Factor E2‑related Factor 2 Hepatotoxicity Oxidative Stress
DOI10.1186/s13020-017-0153-x
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000414206700002
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Room 6034, Building N22, Avenida da Universidade, Macao, People’s Republic of China
2.Sichuan New Lotus Traditional Chinese Herb Limited Company, Chengdu, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, M,Zhang, XJ,Feng, RB,et al. Hepatoprotective properties of &ITPenthorum chinense&IT Pursh against carbon tetrachloride-induced acute liver injury in mice[J]. CHINESE MEDICINE,2017,12.
APA Wang, M.,Zhang, XJ.,Feng, RB.,Jiang, Y.,Zhang, DY.,...&Wan, JB.(2017).Hepatoprotective properties of &ITPenthorum chinense&IT Pursh against carbon tetrachloride-induced acute liver injury in mice.CHINESE MEDICINE,12.
MLA Wang, M,et al."Hepatoprotective properties of &ITPenthorum chinense&IT Pursh against carbon tetrachloride-induced acute liver injury in mice".CHINESE MEDICINE 12(2017).
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