UM  > 中華醫藥研究院
Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice
Yanbei Tu; Kai Wang; Jian-Bo Wan; Chengwei He
2019-11
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume62
Abstract

Glycine tabacina (Labill.) Benth, a renowned Chinese medicinal herb, has been used for treatment of rheumatoid arthritis (RA) and joint infection. This study aimed to investigate inhibitory effect of its ethanol extract (GTE) on RA-associated inflammation. Nine isoflavonoids of twelve ones which were found in G. tabacina roots were identified by UHPLC-DAD-MS/MS. GTE treatment suppressed lipopolysaccharide-stimulated overproduction of nitric oxide, TNF-α and IL-6, and iNOS expression in macrophages. GTE blocked the activation of NF-κB and MAPK pathways, as indicated by reduced levels of phosphorylation of IKKα/β, IκBα, p38, ERK and JNK, and the suppressed nuclear translocation of NF-κB p65. Additionally, GTE administration decreased swelling of arthritic paw and serum TNF-α and IL-1β levels in collagen-induced arthritis (CIA) mice. These results demonstrated that GTE exhibited strong anti-inflammatory and anti-arthritic activities through suppressing NF-κB and MAPK pathways activation in activated macrophages and CIA mice, suggesting the potential applications of this species in RA prevention and treatment as functional food or therapeutic agent.

KeywordGlycine Tabacina Anti-inflammation Raw 264.7 Macrophages Nf-κb Rheumatoid Arthritis
DOI10.1016/j.jff.2019.103528
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000491207500019
全文获取链接
引用统计
Document TypeJournal article
专题Institute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Researchin Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao SAR 999078,China
First Author AffilicationInstitute of Chinese Medical Sciences
推荐引用方式
GB/T 7714
Yanbei Tu,Kai Wang,Jian-Bo Wan,et al. Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice[J]. JOURNAL OF FUNCTIONAL FOODS,2019,62.
APA Yanbei Tu,Kai Wang,Jian-Bo Wan,&Chengwei He.(2019).Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice.JOURNAL OF FUNCTIONAL FOODS,62.
MLA Yanbei Tu,et al."Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice".JOURNAL OF FUNCTIONAL FOODS 62(2019).
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
Google Scholar
中相似的文章 Google Scholar
[Yanbei Tu]的文章
[Kai Wang]的文章
[Jian-Bo Wan]的文章
Baidu academic
中相似的文章 Baidu academic
[Yanbei Tu]的文章
[Kai Wang]的文章
[Jian-Bo Wan]的文章
Bing Scholar
中相似的文章 Bing Scholar
[Yanbei Tu]的文章
[Kai Wang]的文章
[Jian-Bo Wan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。