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Role of amyloid β protein receptors in mediating synaptic plasticity (Review)
YU LI1; ZHONGQING SUN1; QIAOYU CAO1; MEIWAN CHEN2; HUANMIN LUO1; XI LIN1; FEI XIAO1
2017-04
Source PublicationBIOMEDICAL REPORTS
ISSN2049-9434
Volume6Issue:4Pages:379-386
Abstract

There are few diseases in modern biomedicine that have garnered as much scientific interest and public concern as Alzheimer's disease (AD). The amyloid hypothesis has become the dominant model of AD pathogenesis; however, the details of the hypothesis are changing over time. Recently, given the increasing recognition, subtle effects of amyloid β protein (Aβ) on synaptic efficacy may be critical to AD progression. Synaptic plasticity is the important neurochemical foundation of learning and memory. Recent studies have identified that soluble Aβ oligomers combine with certain receptors to impair synaptic plasticity in AD, which advanced the amyloid hypothesis. The aim of the present review was to summarize the role of Aβ‑relevant receptors in regulating synaptic plasticity and their downstream signaling cascades, which may provide novel insights into the understanding of the pathogenesis of AD and the development of therapeutic strategies to slow down the progression of AD‑associated memory decline in the early stages.

KeywordAlzheimer's Disease Ad Pathogenesis Amyloid β Protein Synaptic Plasticity
DOI10.3892/br.2017.863
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000399926400003
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Pharmacology, School of Medicine, Jinan University, Guangzhou,Guangdong 510632
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences, University of Macau, Macau 999078, P.R. China
Recommended Citation
GB/T 7714
YU LI,ZHONGQING SUN,QIAOYU CAO,et al. Role of amyloid β protein receptors in mediating synaptic plasticity (Review)[J]. BIOMEDICAL REPORTS,2017,6(4):379-386.
APA YU LI.,ZHONGQING SUN.,QIAOYU CAO.,MEIWAN CHEN.,HUANMIN LUO.,...&FEI XIAO.(2017).Role of amyloid β protein receptors in mediating synaptic plasticity (Review).BIOMEDICAL REPORTS,6(4),379-386.
MLA YU LI,et al."Role of amyloid β protein receptors in mediating synaptic plasticity (Review)".BIOMEDICAL REPORTS 6.4(2017):379-386.
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