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Aging Converts Innate B1a Cells into Potent CD8(+) T Cell Inducers
Catalina Lee-Chang1,2,3; Monica Bodogai1; Kanako Moritoh1; Xin Chen4,5; Robert Wersto6; Ranjan Sen7; Howard A. Young5; Michael Croft8; Luigi Ferrucci9; Arya Biragyn1
2016-04
Source PublicationJOURNAL OF IMMUNOLOGY
ISSN0022-1767
Volume196Issue:8Pages:3385-3397
Abstract

B cell dysregulation in aging is thought to mostly occur in conventional B2 cells without affecting innate B1 cells. Elderly humans and mice also accumulate 4-1BBL(+)MHC class-I(Hi)CD86(Hi)B cells of unknown origin. In this article, we report that these cells, termed 4BL cells, are activated murine and possibly human B1a cells. The activation is mediated by aging human monocytes and murine peritoneal macrophages. They induce expression and activation of 4-1BBL and IFN-γR1 on B1a cells to subsequently upregulate membrane TNF-α and CD86. As a result, activated B1a/4BL cells induce expression of granzyme B in CD8(+)T cells by targeting TNFR2 via membrane TNF-α and providing costimulation with CD86. Thus, for the first time, to our knowledge, these results indicate that aging affects the function of B1a cells. Upon aging, these cells lose their tumor-supporting activity and become inducers of potentially antitumor and autoimmune CD8(+)T cells.

DOI10.4049/jimmunol.1502034
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000373721900017
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Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Immunoregulation Section, National Institute on Aging, Baltimore, MD 21224
2.INSERM UMR995, Lille Inflammation Research International Center, F-59000 Lille, France
3.University of Lille, F-59000 Lille, France
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, Uni- versity of Macau, Macao Special Administrative Region, People’s Republic of China
5.Cancer and Inflammation Program, Natio nal Cancer Institute, Frederick, MD 21702
6.Flow Cytometry Unit, National Institute on Aging, Baltimore, MD 21244
7.Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224
8.Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037
9.Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224
Recommended Citation
GB/T 7714
Catalina Lee-Chang,Monica Bodogai,Kanako Moritoh,et al. Aging Converts Innate B1a Cells into Potent CD8(+) T Cell Inducers[J]. JOURNAL OF IMMUNOLOGY,2016,196(8):3385-3397.
APA Catalina Lee-Chang.,Monica Bodogai.,Kanako Moritoh.,Xin Chen.,Robert Wersto.,...&Arya Biragyn.(2016).Aging Converts Innate B1a Cells into Potent CD8(+) T Cell Inducers.JOURNAL OF IMMUNOLOGY,196(8),3385-3397.
MLA Catalina Lee-Chang,et al."Aging Converts Innate B1a Cells into Potent CD8(+) T Cell Inducers".JOURNAL OF IMMUNOLOGY 196.8(2016):3385-3397.
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