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A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis inBreast Cancer Immunotherapy
Mohammad A. I. Al-Hatamleh1; Suhana Ahmad1; Jennifer C. Boer2; JitKang Lim3; Xin Chen4; Magdalena Plebanski5; Rohimah Mohamud1,6
2019
Source PublicationJOURNAL OF ONCOLOGY
ISSN1687-8450
Volume2019
Other Abstract

In the past decade, nanomedicine research has provided us with highly useful agents (nanoparticles) delivering therapeutic drugs to target cancer cells. The present review highlights nanomedicine applications for breast cancer immunotherapy. Recent studies have suggested that tumour necrosis factor (TNF) and its receptor 2 (TNFR2) expressed on breast cancer cells have important functional consequences. This cytokine/receptor interaction is also critical for promoting highly immune-suppressive phenotypes by regulatory T cells (Tregs). This review generally provides a background for nanoparticles as potential drug delivery agents for immunomodulators and further discusses in depth the potential of TNF antagonists delivery to modulate TNF-TNFR2 interactions and inhibit breast cancer progression.

DOIhttps://doi.org/10.1155/2019/6313242
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000470177800001
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan 16150, Malaysia
2.Department of Immunology and Pathology, Monash University, Melbourne 3168 ,Australia
3.School of Chemical Engineering, Universiti Sains Malaysia, Penang14300, Malaysia
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Macau SAR 999078 , China
5.School of Health and Biomedical Sciences, RMIT University, Bundoora 3083, Australia
6.Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan16150, Malaysia
Recommended Citation
GB/T 7714
Mohammad A. I. Al-Hatamleh,Suhana Ahmad,Jennifer C. Boer,et al. A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis inBreast Cancer Immunotherapy[J]. JOURNAL OF ONCOLOGY,2019,2019.
APA Mohammad A. I. Al-Hatamleh.,Suhana Ahmad.,Jennifer C. Boer.,JitKang Lim.,Xin Chen.,...&Rohimah Mohamud.(2019).A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis inBreast Cancer Immunotherapy.JOURNAL OF ONCOLOGY,2019.
MLA Mohammad A. I. Al-Hatamleh,et al."A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis inBreast Cancer Immunotherapy".JOURNAL OF ONCOLOGY 2019(2019).
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