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Water-soluble small-molecule probes for RNA based on a two-photon fluorescence "off-on'' process: systematic analysis in live cell imaging and understanding of structure-activity relationships
Li, Hong1,2; Li, Yuncang3; Zhang, Huihui1,2; Xu, Guoyong1,2; Zhang, Yuliang1,2; Liu, Xiaohu1,2; Zhou, Hongping1,2; Yang, Xingyuan3; Zhang, Xuanjun4; Tian, Yupeng1,2
2017-12-25
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume53Issue:99Pages:13245-13248
Abstract

The conveniently obtained water-soluble small-molecule L1-5 were selective for RNA with remarkable "off-on'' two-photon fluorescence responses in vitro and in vivo, showing that L1-5 can surprisingly stain mitochondria or nucleoli individually with orange fluorescence under different focal lengths. Compounds L6-8 were prepared, for comparison, to further explore the mechanism of the binding of L1-5 with RNA, which revealed that the synergistic effect of the amino group and the pyridinium cation played a significant role in distinct cell imaging.

DOI10.1039/c7cc07288k
URLView the original
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000417959200012
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Anhui Univ, Coll Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China
2.Key Labotatory Funct Inorgan Mat Chem Anhui Prov, Hefei 230601, Anhui, Peoples R China
3.Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China
4.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
Recommended Citation
GB/T 7714
Li, Hong,Li, Yuncang,Zhang, Huihui,et al. Water-soluble small-molecule probes for RNA based on a two-photon fluorescence "off-on'' process: systematic analysis in live cell imaging and understanding of structure-activity relationships[J]. CHEMICAL COMMUNICATIONS,2017,53(99):13245-13248.
APA Li, Hong.,Li, Yuncang.,Zhang, Huihui.,Xu, Guoyong.,Zhang, Yuliang.,...&Tian, Yupeng.(2017).Water-soluble small-molecule probes for RNA based on a two-photon fluorescence "off-on'' process: systematic analysis in live cell imaging and understanding of structure-activity relationships.CHEMICAL COMMUNICATIONS,53(99),13245-13248.
MLA Li, Hong,et al."Water-soluble small-molecule probes for RNA based on a two-photon fluorescence "off-on'' process: systematic analysis in live cell imaging and understanding of structure-activity relationships".CHEMICAL COMMUNICATIONS 53.99(2017):13245-13248.
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