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Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella
Xiao-JunHuang1,2; Si Wen1,2; Xi-FengGuan1,2; Zhen-LongWu1,2; Man-MeiLi1; Chun-LinFan1,2; Qing-WenZhang3; GingChan3; YingWang1,2; Wen-CaiYe1,2
2019
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Volume16Issue:7
Abstract

Asprellosides A‐K, nine new ursane‐type triterpenoid glycosides (19), and two new oleanane‐type triterpenoid glycosides (10 and 11), including six rare sulfated triterpenoid glycosides, were isolated from the roots of Ilex asprella. Their structures were determined on the basis of comprehensive spectroscopic analysis and chemical methods. Among these compounds, asprelloside B (2) and asprelloside C (3) are the first examples of triterpenoid glycosides bearing a rare 3,4‐O‐disulfo‐xylopyranosyl residue. All the saponins isolated showed no significant effects against respiratory syncytial virus (RSV) and lipopolysaccharide‐induced nitric oxide production in Raw264.7 macrophages.

KeywordCytotoxicity Aquifoliaceae Ilex Asprella Triterpenoid Glycoside Disulfated Triterpenoid Glycoside Phytochemistry
DOI10.1002/cbdv.201900202
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000475989600009
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Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorYingWang
Affiliation1.Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632 P. R. China
2.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632 P. R. China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, P. R. China
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Xiao-JunHuang,Si Wen,Xi-FengGuan,et al. Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella[J]. CHEMISTRY & BIODIVERSITY,2019,16(7).
APA Xiao-JunHuang.,Si Wen.,Xi-FengGuan.,Zhen-LongWu.,Man-MeiLi.,...&Wen-CaiYe.(2019).Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella.CHEMISTRY & BIODIVERSITY,16(7).
MLA Xiao-JunHuang,et al."Eleven New Triterpenoid Glycosides from the Roots of Ilex asprella".CHEMISTRY & BIODIVERSITY 16.7(2019).
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