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BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage
Qin, Li-Xia1; Tan, Jie-qiong2; Zhang, Hai-nan1; Rizwana, Kousar3; Lu, Jia-hong4; Tang, Jian-guang1; Jiang, Bo1; Shen, Xiang-min1; Guo, Ji-feng2,5,6,7; Tang, Bei-sha2,5,6,7; Tan, Li-ming1; Wang, Chun-yu1
2017
Source PublicationOXIDATIVE MEDICINE AND CELLULAR LONGEVITY
ISSN1942-0900
Abstract

Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson's disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.

DOI10.1155/2017/5094934
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000397850200001
PublisherHINDAWI LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Chun-yu
Affiliation1.Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China
2.The State Key Laboratory of Medical Genetics and School of Life Science, Central South University, Changsha, Hunan, China
3.Department of Biology, Allama Iqbal Open University, Islamabad, Pakistan
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
5.Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
6.Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
7.Neurodegenerative Disorders Research Center, Central South University, Changsha, China
Recommended Citation
GB/T 7714
Qin, Li-Xia,Tan, Jie-qiong,Zhang, Hai-nan,et al. BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2017.
APA Qin, Li-Xia.,Tan, Jie-qiong.,Zhang, Hai-nan.,Rizwana, Kousar.,Lu, Jia-hong.,...&Wang, Chun-yu.(2017).BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY.
MLA Qin, Li-Xia,et al."BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017).
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