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Evaluation of Anti proliferative Activities and Action Mechanisms of Extracts from Two Species of Ganoderma on Tumor Cell Lines
YU-WEI LIU; JIAN-LI GAO; JIA GUAN; ZHENG-MING QIAN; KUN FENG; SHAO-PING LI
2009-03-13
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume57Issue:8Pages:3087-3093
Abstract

The antiproliferative activities on tumoral cells, namely, human breast cancer (MCF-7 and MDA-MB-231), hepatoma (HepG2) and myeloid leukemia (HL-60), of ethanolic extracts from two species of Ganoderma, G. lucidum and G. sinense, were investigated. Though both extracts had certain antiproliferative activities, their chemical characteristics, including nucleosides, triterpenoids and sterols, were significantly different. Their effects on MDA-MB-231 cells were further studied using apoptotic detection and cell cycle analyses. As a result, both had apoptosis induction through the alternation of mitochondrial transmembrane depolarization, though no triterpenoids were detected in ethanolic extract of G. sinense. Furthermore, the two extracts from G. lucidum and G. sinense could arrest cell cycle at different phases. This study showed that ethanol extracts of both G. lucidum and G. sinense have antitumoral proliferation effect through both apoptosis pathway and cell cycle arrest effect, and some other compounds such as sterols and/or nucleosides may contribute to their activity besides triterpenoids.

KeywordGanoderma Lucidum Ganoderma Sinense Antiproliferation Cell Cycle Apoptosis
DOI10.1021/jf900011f
Indexed BySCI
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000265227600012
PublisherAMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
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Cited Times [WOS]:56   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSHAO-PING LI
AffiliationInstitute of Chinese Medical Sciences, University of Macau, Macao SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
YU-WEI LIU,JIAN-LI GAO,JIA GUAN,et al. Evaluation of Anti proliferative Activities and Action Mechanisms of Extracts from Two Species of Ganoderma on Tumor Cell Lines[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2009,57(8):3087-3093.
APA YU-WEI LIU,JIAN-LI GAO,JIA GUAN,ZHENG-MING QIAN,KUN FENG,&SHAO-PING LI.(2009).Evaluation of Anti proliferative Activities and Action Mechanisms of Extracts from Two Species of Ganoderma on Tumor Cell Lines.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,57(8),3087-3093.
MLA YU-WEI LIU,et al."Evaluation of Anti proliferative Activities and Action Mechanisms of Extracts from Two Species of Ganoderma on Tumor Cell Lines".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 57.8(2009):3087-3093.
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