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Isolation and Identification of Two New Polyynes from a North American Ethnic Medicinal Plant-Oplopanax horridus (Smith) Miq.
Wei-Hua Huang1; Qing-Wen Zhang1; Chong-Zhi Wang2; Chun-Su Yuan2; Shao-Ping Li1
2010-02-23
Source PublicationMOLECULES
ISSN1420-3049
Volume15Issue:2Pages:1089-1096
Abstract

Two new polyynes, named oplopantriol A (5) and oplopantriol B (6), were isolated from the root bark of Oplopanax horridus (Smith) Miq, an ethnic medicinal plant of North America, along with four known polyynes: (3S,8S)-falcarindiol (1), oplopandiol (2), (11S,16S,9Z)-9,17-octadecadiene-12,14-diyne-1,11,16-triol, 1-acetate (3) and oplopandiol acetate (4). The structures of the new compounds were elucidated by detailed spectroscopic analyses, including 1D and 2D NMR techniques and chemical methods. The absolute configurations of the new compounds 5 and 6 were determined by comparing their optical rotation values with the hydrolysis products of the known compounds 3 and 4, respectively, derived from the same plant. On the basis of an analysis of their physical and chemical properties we show that the alkaline hydrolysis of 3 and 4 afforded the new compounds 5 and 6, respectively.

KeywordOplopanax Horridus Polyyne Oplopantriol a And b Alkaline Hydrolysis
DOI10.3390/molecules15021089
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000274929200035
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被引频次[WOS]:21   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorQing-Wen Zhang; Shao-Ping Li
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Macao, China; E-Mail:endeavor34852@yahoo.com.cn (W.-H.H.)
2.Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA; E-Mails: czwang@dacc.uchicago.edu (C.-Z.W.); CYuan@dacc.uchicago.edu (C.-S.Y.)
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
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Wei-Hua Huang,Qing-Wen Zhang,Chong-Zhi Wang,et al. Isolation and Identification of Two New Polyynes from a North American Ethnic Medicinal Plant-Oplopanax horridus (Smith) Miq.[J]. MOLECULES,2010,15(2):1089-1096.
APA Wei-Hua Huang,Qing-Wen Zhang,Chong-Zhi Wang,Chun-Su Yuan,&Shao-Ping Li.(2010).Isolation and Identification of Two New Polyynes from a North American Ethnic Medicinal Plant-Oplopanax horridus (Smith) Miq..MOLECULES,15(2),1089-1096.
MLA Wei-Hua Huang,et al."Isolation and Identification of Two New Polyynes from a North American Ethnic Medicinal Plant-Oplopanax horridus (Smith) Miq.".MOLECULES 15.2(2010):1089-1096.
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