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Core-shell and co-doped nanoscale metal-organic particles (NMOPs) obtained via post-synthesis cation exchange for multimodal imaging and synergistic thermo-radiotherapy
Yang, Yu1; Chao, Yu2; Liu, Jingjing2; Dong, Ziliang2; He, Weiwei3; Zhang, Rui2; Yang, Kai3; Chen, Meiwan1; Liu, Zhuang2
2017-01
Source PublicationNPG ASIA MATERIALS
ISSN1884-4049
Volume9
Abstract

Nanoscale metal-organic particles (NMOPs) have recently shown great promise in the area of nanomedicine owing to their tunable compositions, highly enriched functionalities, well-defined sizes/shapes and intrinsic biodegradability. Herein, we describe the fabrication of NMOPs with both core-shell and co-doped structures via a post-synthesis cation exchange method for applications in multimodal imaging and combined photothermal and radiation therapy of cancer. Template NMOPs containing Mn2+ and IR825, a near-infrared (NIR) dye, are first synthesized and then mixed with Hf4+ to obtain core-shell and co-doped Mn/Hf-IR825 NMOPs depending on the dose of added Hf4+ ions. In these NMOPs, Mn2+ offers strong T1 magnetic resonance (MR) contrast, Hf4+ is a high-Z element with excellent computed tomography signal enhancement ability and radio-sensitization capability, and IR825 exhibits rather high NIR absorbance. After coating with polydopamine (PDA) and further conjugation with polyethylene glycol (PEG), the co-doped Mn/Hf-IR825@PDA-PEG particles (NMOP-PEG) showed efficient tumor-homing ability after intravenous injection, as illustrated by MR and photoacoustic (PA) imaging. Utilizing NMOP-PEG achieved excellent tumor killing efficacy through in vivo photothermal and radiation synergistic therapy in our mouse tumor model experiments. Importantly, our NMOP-PEG showed no appreciable toxicity to the treated mice and could be efficiently excreted. Our work presents a facile method to fabricate NMOP-PEG with multi-component structures as a biodegradable, multifunctional nanoplatform for multimodal image-guided combination cancer therapy.

DOI10.1038/am.2016.205
URLView the original
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000393795000005
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, Meiwan; Liu, Zhuang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau, China
2.Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Jiangsu, China
3.School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Jiangsu, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang, Yu,Chao, Yu,Liu, Jingjing,et al. Core-shell and co-doped nanoscale metal-organic particles (NMOPs) obtained via post-synthesis cation exchange for multimodal imaging and synergistic thermo-radiotherapy[J]. NPG ASIA MATERIALS,2017,9.
APA Yang, Yu.,Chao, Yu.,Liu, Jingjing.,Dong, Ziliang.,He, Weiwei.,...&Liu, Zhuang.(2017).Core-shell and co-doped nanoscale metal-organic particles (NMOPs) obtained via post-synthesis cation exchange for multimodal imaging and synergistic thermo-radiotherapy.NPG ASIA MATERIALS,9.
MLA Yang, Yu,et al."Core-shell and co-doped nanoscale metal-organic particles (NMOPs) obtained via post-synthesis cation exchange for multimodal imaging and synergistic thermo-radiotherapy".NPG ASIA MATERIALS 9(2017).
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