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Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors
Gan, Jingjing1; Dou, Yunyan1; Li, Yurong1; Wang, Zhenzhen1; Wang, Lintao1; Liu, Shang1; Li, Qiu2; Yu, Heran1; Liu, Chunyan1; Han, Congwei1; Huang, Zhen1; Zhang, Junfeng1,3; Wang, Chunming2; Dong, Lei1
2018-09
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume178Pages:95-108
Abstract

Macrophages are highly plastic cells that can either mediate or suppress inflammation, depending on their cellular phenotype and cytokine secretion. Inducing macrophages from an inflammatory ('M1') to anti-inflammatory ('M2') phenotype has significant implications for the treatment of inflammatory diseases and regeneration of injured tissues. Although certain cytokines, such as interleukin-4 and -13, are known to induce this phenotypic switch, their therapeutic use in vivo has both safety and efficacy concerns. Here, we demonstrate an alternative approach to change macrophage phenotype from M1 to M2, through inducing the clustering of mannose receptors (MR) on the cell surface, by using carbohydrate-presenting substrates. We prepared and screened glucomannan-decorated silicon oxide of different sizes ranging from 10 to 1000 nm, and identified one type (KSiNP30) that could potently induce MR clustering on macrophages and thereby stimulated the cells into an M2 phenotype - as an unexpected consequence of MR activation. Further administration of KSiNP30 in a murine model of inflammatory bowel disease efficiently alleviated the colitis symptoms, indicating the translational potential of our finding for therapeutic applications. In summary, we report for the first time an approach to modulate cellular immune responses by manipulating the assembly of cell-surface receptors, without the aid of cytokines. Our approach may provide insights for the development of new anti-inflammatory therapies. (C) 2018 Elsevier Ltd. All rights reserved.

KeywordMacrophage Inflammatory Bowel Disease Nanoparticle Receptor Clustering
DOI10.1016/j.biomaterials.2018.06.015
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000440959000009
PublisherELSEVIER SCI LTD
The Source to ArticleWOS
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang, Junfeng; Wang, Chunming; Dong, Lei
Affiliation1.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210093, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
3.Jiangsu Provincial Laboratory for Nano-Technology, Nanjing University, Nanjing, 210093, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Gan, Jingjing,Dou, Yunyan,Li, Yurong,et al. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors[J]. BIOMATERIALS,2018,178:95-108.
APA Gan, Jingjing.,Dou, Yunyan.,Li, Yurong.,Wang, Zhenzhen.,Wang, Lintao.,...&Dong, Lei.(2018).Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors.BIOMATERIALS,178,95-108.
MLA Gan, Jingjing,et al."Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors".BIOMATERIALS 178(2018):95-108.
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