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Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
Lei, Haipeng; Deng, Chu-Xia

Fibroblast growth factor receptor 2 (FGFR2) is a membrane-spanning tyrosine kinase that mediates signaling for FGFs. Recent studies detected various point mutations of FGFR2 in multiple types of cancers, including breast cancer, lung cancer, gastric cancer, uterine cancer and ovarian cancer, yet the casual relationship between these mutations and tumorigenesis is unclear. Here we will discuss possible interactions between FGFR2 signaling and several major pathways through which the aberrantly activated FGFR2 signaling may result in breast cancer development. We will also discuss some recent developments in the discovery and application of therapies and strategies for breast cancers by inhibiting FGFR2 activities.

KeywordBreast Cancer Fgfr2 Mutation Polymorphism Inhibitor
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Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000410588700007
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDeng, Chu-Xia
AffiliationFaculty of Health Sciences, University of Macau, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Lei, Haipeng,Deng, Chu-Xia. Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2017,13(9):1163-1171.
APA Lei, Haipeng,&Deng, Chu-Xia.(2017).Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,13(9),1163-1171.
MLA Lei, Haipeng,et al."Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13.9(2017):1163-1171.
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