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Design and development of a piezo-driven microinjection system with force feedback
Wang, Guangwei; Xu, Qingsong

This paper presents the design and development of a novel piezo-driven cell injection system with force feedback, which overcomes the unsatisfied force interaction between the pipette needle and embryos in conventional position control. By integrating semiconductor strain-gage sensors for detecting the cell penetration force and the micropipette relative position in real time, the developed cell microinjection system features high operation speed, confident success rate, and high survival rate. The effectiveness of the developed cell injection system is experimentally verified by penetrating zebrafish embryos. The injection of 100 embryos are conducted with separate position control and force control. Results indicate that the force control enables a survival rate of 86%, which is higher than the survival rate of 82% produced by the position control in the same control environment. The experimental results quantitatively demonstrate the superiority of force control over conventional position control for the first time.

KeywordPosition Control Force Control Piezoelectrical Actuator Cell Injection Zebrafish Embryos
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Indexed BySCI
WOS Research AreaRobotics
WOS SubjectRobotics
WOS IDWOS:000423295200009
The Source to ArticleWOS
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
AffiliationUniv Macau, Fac Sci & Technol, Dept Electromech Engn, Macau, Peoples R China.
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang, Guangwei,Xu, Qingsong. Design and development of a piezo-driven microinjection system with force feedback[J]. ADVANCED ROBOTICS,2017,31(23-24):1349-1359.
APA Wang, Guangwei,&Xu, Qingsong.(2017).Design and development of a piezo-driven microinjection system with force feedback.ADVANCED ROBOTICS,31(23-24),1349-1359.
MLA Wang, Guangwei,et al."Design and development of a piezo-driven microinjection system with force feedback".ADVANCED ROBOTICS 31.23-24(2017):1349-1359.
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