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Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review
Liu, Yuling1; Cai, Yuee1; He, Chengwei1; Chen, Meiwan1; Li, Hui2
2017
Source PublicationAMERICAN JOURNAL OF CHINESE MEDICINE
ISSN0192-415X
Volume45Issue:3Pages:423-441
Abstract

It has been shown that plumbagin, a bioactive naphthoquinone isolated from three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae, definitively exhibits anticancer potential in diverse cancer cells both in vitro and in vivo. Plumbagin shows antineoplastic effects via multi-channel molecular mechanisms, including the induction of apoptosis and autophagy, the disruption of the cell cycle, the inhibition of invasion and metastasis, and anti-angiogenesis. Plumbagin inhibits the growth of cancer cells mainly through the modulation of the signals of PI3K/Akt/mTOR, AMPK, Ras, and so on. The pharmaceutical applications of plumbagin combined with nanocarriers to achieve better therapeutic efficiency are discussed in this review Among them, liposomes, nanoparticles, microspheres, micelles, and nisosomes are used in cancer treatment. The anticancer study of plumbagin in vivo is also summarized in this review. On the whole, we aim to review the research progress of plumbagin both in pharmacological and pharmaceutical filed, which may provide some reference for further research of plumbagin.

KeywordPlumbagin Anticancer Activities Molecular Mechanisms Pharmaceutical Applications Review
DOI10.1142/S0192415X17500264
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000402314500002
PublisherWORLD SCIENTIFIC PUBL CO PTE LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, Meiwan; Li, Hui
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, P.R. China
2.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu, Yuling,Cai, Yuee,He, Chengwei,et al. Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2017,45(3):423-441.
APA Liu, Yuling,Cai, Yuee,He, Chengwei,Chen, Meiwan,&Li, Hui.(2017).Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review.AMERICAN JOURNAL OF CHINESE MEDICINE,45(3),423-441.
MLA Liu, Yuling,et al."Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review".AMERICAN JOURNAL OF CHINESE MEDICINE 45.3(2017):423-441.
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