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A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb
Li, Yun-xia1,2; Gong, Xiao-hong2; Liu, Mei-chen2; Peng, Cheng2; Li, Peng1; Wang, Yi-tao1
2017
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Abstract

Polygonum multiflorum Thunb. (HSW) is widely used as herb medicine and health food additive. Recently, a series of HSW-induced hepatotoxicities have been reported and many studies have been carried out to investigate it. But contradictory conclusions were drawn that might be caused by the inconsistent quality of market decoction pieces. Therefore, the HSW decoction pieces quality was evaluated with a developed novel method in the paper. 25 batches of raw HSW (RHSW) and 21 batches of processed HSW (PHSW) samples were purchased from different provinces of China. HPLC determination was performed to identify and detect the contents of 16 chemical compounds in herbal material. Fingerprint similarity was analyzed using chromatography information and the results showed that most herbs were in good similarity. Then, a comprehensive evaluation strategy based on principal component analysis with representative quality control indicators was developed to evaluate the quality of HSW samples. And the rationality of the developed method was verified by HCA analysis. The results showed that the herb from Dabashan, Sichuan Province, no matter RHSW or PHSW had the best quality. Different representative components were selected for RHSW or PHSW decoction pieces which might be caused by the chemical reaction during processing. And most PHSW were unqualified according to the requirement of Chinese Pharmacopeia which might take the responsibility for the toxicity of HSW.

DOIhttp://doi.org/10.1155/2017/6238464
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000394211600001
PublisherHINDAWI LTD
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorPeng, Cheng; Li, Peng
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau
2.Pharmacy College, Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Yun-xia,Gong, Xiao-hong,Liu, Mei-chen,et al. A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017.
APA Li, Yun-xia,Gong, Xiao-hong,Liu, Mei-chen,Peng, Cheng,Li, Peng,&Wang, Yi-tao.(2017).A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Li, Yun-xia,et al."A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017).
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