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Pluronic F68-Linoleic Acid Nano-spheres Mediated Delivery of Gambogic Acid for Cancer Therapy
Fang, Xiaobin; Xu, Yingqi; Wang, Shengpeng; Wan, Jianbo; He, Chengwei; Chen, Meiwan
2017-01
Source PublicationAAPS PHARMSCITECH
ISSN1530-9932
Volume18Issue:1Pages:147-155
Abstract

Gambogic acid (GA), a natural compound from gamboge resin, has been introduced as a promising antitumor drug contributing to its broad spectrum of antitumor activity. However, the poor aqueous solubility and short half-life hinder its clinical application. Pluronic F68 (F68) is a well-known amphiphilic block copolymer consisting of hydrophobic propylene oxide units and hydrophilic ethylene oxide. Although F68 has an amphiphilic structure, its short propylene oxide segment limits its dilution stability and drug-loading capacity. To overcome this limitation, we modified F68 by conjugating linoleic acid, a hydrophobic fatty acid, to increase the hydrophilic-hydrophobic interaction and thus improve the stability of F68 nano-spheres. This F68-linoleic acid (F68-LA) conjugate was synthesized and was used to load GA to improve its anticancer effects. GA-loaded F68-LA nano-spheres were stable for 6 days, with a mean diameter of 159.3 nm and zeta potential of -23.2 mV. The entrapment efficiency of GA in F68-LA nano-spheres was as high as 92.0%. Furthermore, F68-LA/GA nano-spheres exhibited an enhanced cytotoxic activity and proapoptotic effect against human ovarian cancer A2780 cells, compared with free GA. Our results showed that the F68-LA/GA nano-spheres might be a promising cancer-targeted drug delivery system in ovarian cancer therapy.

KeywordAnticancer Gambogic Acid Linoleic Acid Nano-spheres Pluronic F68
DOI10.1208/s12249-015-0473-z
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000392104200016
PublisherSPRINGER
The Source to ArticleWOS
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被引频次[WOS]:5   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorChen, Meiwan
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical SciencesUniversity of MacauMacauChina
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
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Fang, Xiaobin,Xu, Yingqi,Wang, Shengpeng,et al. Pluronic F68-Linoleic Acid Nano-spheres Mediated Delivery of Gambogic Acid for Cancer Therapy[J]. AAPS PHARMSCITECH,2017,18(1):147-155.
APA Fang, Xiaobin,Xu, Yingqi,Wang, Shengpeng,Wan, Jianbo,He, Chengwei,&Chen, Meiwan.(2017).Pluronic F68-Linoleic Acid Nano-spheres Mediated Delivery of Gambogic Acid for Cancer Therapy.AAPS PHARMSCITECH,18(1),147-155.
MLA Fang, Xiaobin,et al."Pluronic F68-Linoleic Acid Nano-spheres Mediated Delivery of Gambogic Acid for Cancer Therapy".AAPS PHARMSCITECH 18.1(2017):147-155.
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