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ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders
Chong, Cheong-Meng; Ai, Nana; Lee, Simon Ming-Yuen
2017
Source PublicationCURRENT DRUG TARGETS
ISSN1389-4501
Volume18Issue:4Pages:455-462
Abstract

Rho-associated protein kinase (ROCK) is a serine-threonine kinase originally identified as a crucial regulator of actin cytoskeleton. Recent studies have defined new functions of ROCK as a critical component of diverse signaling pathways in neurons. In addition, inhibition of ROCK causes several biological events such as increase of neurite outgrowth, axonal regeneration, and activation of prosurvival Akt. Thus, it has attracted scientist's strong attentions and considered ROCK as a promising therapeutic target for the treatment of neurodegenerative disorders including Alzheimer disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. However, ROCK has two highly homologous isoforms, ROCK1 and ROCK2. Accumulated evidences indicate that ROCK1 and ROCK2 might involve in distinct cellular functions in central nervous system (CNS) and neurodegenerative processes. This review summarizes recent updates regarding ROCK isoformspecific functions in CNS and the progress of ROCK inhibitors in preclinical studies for neurodegenerative diseases.

KeywordAxonal Regeneration Central Nervous System Fasudil Isoforms Limk Neurodegenerative Diseases Rock
DOI10.2174/1389450117666160401123825
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000394389200010
PublisherBENTHAM SCIENCE PUBL LTD
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLee, Simon Ming-Yuen
AffiliationUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China.
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chong, Cheong-Meng,Ai, Nana,Lee, Simon Ming-Yuen. ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders[J]. CURRENT DRUG TARGETS,2017,18(4):455-462.
APA Chong, Cheong-Meng,Ai, Nana,&Lee, Simon Ming-Yuen.(2017).ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders.CURRENT DRUG TARGETS,18(4),455-462.
MLA Chong, Cheong-Meng,et al."ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders".CURRENT DRUG TARGETS 18.4(2017):455-462.
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