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Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus
Bao, Jiaolin1; Ding, Ren-Bo2; Liang, Yeer1; Liu, Fang1; Wang, Kai1; Jia, Xuejing1; Zhang, Chao1; Chen, Meiwan1; Li, Peng1; Su, Huanxing1; Wan, Jian-Bo1; Wang, Yitao1; He, Chengwei1
2017
Source PublicationAMERICAN JOURNAL OF CHINESE MEDICINE
ISSN0192-415X
Volume45Issue:7Pages:1513-1536
Abstract

Forsythiae Fructus, Lianqiao in Chinese, is one of the most fundamental herbs in Traditional Chinese Medicine. Both green Forsythia (GF) and ripe Forsythia (RF) are referred to Forsythiae Fructus in medicinal applications. In most cases, they are used without distinction. In this study, a metabolomics approach was performed to compare componential differences of two Forsythiae Fructus aqueous extracts subtypes. Principal component analysis (PCA) score plots from the UPLC-MS data showed clear separation between the two subtypes, indicating there are significant differences in the chemical components between GF and RF. Meanwhile, the anticancer activity of them was also compared. GF exhibited much stronger antitumor activity than RF against B16-F10 murine melanoma both in vitro and in vivo. 15 chemical compounds were identified as specific markers for distinguishing GF and RF. Among these marker compounds, forsythoside I, forsythoside A, forsythoside E and pinoresinol were demonstrated to be key important active compounds that account for the different anticancer efficacies of GF and RF. Our data suggest that GF and RF should be distinctively used in clinical applications, particularly in the anticancer formulas, in which GF should be preferentially prescribed.

KeywordForsythia Suspensa Metabolomics Forsythoside Anticancer B16 Melanoma
DOIhttp://doi.org/10.1142/S0192415X17500823
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000413035200010
PublisherWORLD SCIENTIFIC PUBL CO PTE LTD
The Source to ArticleWOS
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, P. R. China
2.Faculty of Health Sciences, University of Macau, Macao 999078, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Bao, Jiaolin,Ding, Ren-Bo,Liang, Yeer,et al. Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2017,45(7):1513-1536.
APA Bao, Jiaolin.,Ding, Ren-Bo.,Liang, Yeer.,Liu, Fang.,Wang, Kai.,...&He, Chengwei.(2017).Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus.AMERICAN JOURNAL OF CHINESE MEDICINE,45(7),1513-1536.
MLA Bao, Jiaolin,et al."Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus".AMERICAN JOURNAL OF CHINESE MEDICINE 45.7(2017):1513-1536.
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