UM  > 健康科學學院
Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer
Wong, Janet P. C.1; Wei, Ran1; Lyu, Peng1; Tong, Olivia L. H.1; Zhang, Shu Dong2; Wen, Qing3; Yuen, Hiu Fung4; El-Tanani, Mohamed5; Kwok, Hang Fai1
2017
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume13Issue:11Pages:1373-1386
Abstract

Osteopontin (OPN) plays an important role in cancer progression, however its prognostic significance and its downstream factors are largely elusive. In this study, we have shown that expression of OPN was significantly higher in bladder cancer specimens with higher T-stage or tumor grades. In addition, a high level of OPN was significantly associated with poorer survival in two independent bladder cancer patient cohorts totaling 389 bladder cancer patients with available survival data. We further identified Matrix metallopeptidase 9 (MMP9) and S100 calcium-binding protein A8 (S100A8) were both downstream factors for OPN in bladder cancer specimens and bladder cancer cell lines. Expression of OPN was significantly positively associated with that of MMP9 and S100A8, while overexpression of OPN resulted in upregulation of MMP9 and S100A8, and knockdown of OPN showed consistent downregulation of MMP9 and S100A8 expression levels. Importantly, expression levels of both MMP9 and S100A8 were significantly associated with higher T-stage, higher tumor grade and a shorter survival time in the bladder cancer patients. Interestingly, OPN expression only predicted survival in MMP9-high, but not MMP9-low subgroups, and in S100A8-low but not S100A8-high subgroups. Our results suggest that OPN, MMP9 and S100A8 all play a significant role in bladder cancer progression and are potential prognostic markers and therapeutic targets in bladder cancer. The mechanistic link between these three genes and bladder cancer progression warrants further investigation.

KeywordOsteopontin Mmp9 S100a8 Bladder Prognosis
DOIhttp://doi.org/10.7150/ijbs.21457
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000414257000003
PublisherIVYSPRING INT PUBL
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorKwok, Hang Fai
Affiliation1.Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau
2.Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, Ulster University, Londonderry, United Kingdom;
3.Center for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, United Kingdom
4.Institute of Molecular and Cell Biology, A*STAR, Singapore
5.Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Wong, Janet P. C.,Wei, Ran,Lyu, Peng,et al. Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2017,13(11):1373-1386.
APA Wong, Janet P. C..,Wei, Ran.,Lyu, Peng.,Tong, Olivia L. H..,Zhang, Shu Dong.,...&Kwok, Hang Fai.(2017).Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,13(11),1373-1386.
MLA Wong, Janet P. C.,et al."Clinical and in vitro analysis of Osteopontin as a prognostic indicator and unveil its potential downstream targets in bladder cancer".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13.11(2017):1373-1386.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wong, Janet P. C.]'s Articles
[Wei, Ran]'s Articles
[Lyu, Peng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wong, Janet P. C.]'s Articles
[Wei, Ran]'s Articles
[Lyu, Peng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wong, Janet P. C.]'s Articles
[Wei, Ran]'s Articles
[Lyu, Peng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.