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Adjunctive minocycline for schizophrenia: A meta-analysis of randomized controlled trials
Xiang, Ying-Qiang1,2; Zheng, Wei3; Wang, Shi-Bin4; Yang, Xin-Hu3; Cai, Dong-Bin5; Ng, Chee H.6; Ungvari, Gabor S.7,8; Kelly, Deanna L.9; Xu, Wei-Ying10; Xiang, Yu-Tao4

This study aimed to conduct a meta-analysis of the efficacy and safety of adjunctive minocycline for schizophrenia. Randomized controlled trials (RCTs) comparing adjunctive minocycline with placebo in patients with schizophrenia were included in the meta-analysis. Two independent investigators extracted and synthesized data. Standard mean differences (SMDs), risk ratio (RR) +/- 95% confidence intervals (CIs) and the number-needed-to-harm (NNH) were calculated. Eight RCTs with 548 schizophrenia patient including 286 (52.2%) patients on minocycline (171.9 +/- 31.2 mg/day) and 262 (47.8%) on placebo completed 18.5 +/- 13.4 weeks of treatment. Meta-analyses of Positive and Negative Syndrome Scale (PANSS) (7 RCTs with 8 treatment arms)/Brief Psychiatric Rating Scale (BPRS) (1 RCT) total score [SMD: -0.64, (95% CI: -1.02, -0.27), P=0.0008; l(2)=74%], positive, negative and general symptom scores [SMD: -0.69 to -0.22 (95%CI: -0.98, -0.03), P=0.02-0.00001; l(2)=7-63%] revealed a significant superiority of adjunctive minocycline treatment over the placebo. There was no significant difference regarding neurocognitive function, discontinuation rate and adverse drug reactions between the two groups. This meta-analysis showed that adjunctive minocycline appears to be efficacious and safe for schizophrenia. Due to significant heterogeneity, future studies with a large sample size are needed to confirm these findings. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.

KeywordSchizophrenia Minocycline Antipsychotic Meta-analysis
URLView the original
Indexed BySCI ; SSCI ; SSCI
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000393244500002
The Source to ArticleWOS
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Cited Times [WOS]:24   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZheng, Wei; Xiang, Yu-Tao
Affiliation1.National Clinical Research Center for Mental Disorders, Beijing, China & Center of Depression, Beijing Institute for Brain Disorders, China
2.Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
3.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
4.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao
5.Faculty of Traditional Chinese Medicine, the First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
6.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
7.The University of Notre Dame Australia/Marian Centre, Perth, Australia
8.School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia
9.Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
10.The Affiliated Hospital of JiangXi University of Traditional Chinese Medicine, Nanchang, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Xiang, Ying-Qiang,Zheng, Wei,Wang, Shi-Bin,et al. Adjunctive minocycline for schizophrenia: A meta-analysis of randomized controlled trials[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2017,27(1):8-18.
APA Xiang, Ying-Qiang.,Zheng, Wei.,Wang, Shi-Bin.,Yang, Xin-Hu.,Cai, Dong-Bin.,...&Xiang, Yu-Tao.(2017).Adjunctive minocycline for schizophrenia: A meta-analysis of randomized controlled trials.EUROPEAN NEUROPSYCHOPHARMACOLOGY,27(1),8-18.
MLA Xiang, Ying-Qiang,et al."Adjunctive minocycline for schizophrenia: A meta-analysis of randomized controlled trials".EUROPEAN NEUROPSYCHOPHARMACOLOGY 27.1(2017):8-18.
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