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Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review
Li, Tiantian1; Ao, Edwin C. I.1; Lambert, Bieke2,3; Brans, Boudewijn4,5; Vandenberghe, Stefaan1; Mok, Greta S. P.6
2017
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume7Issue:18Pages:4551-4565
Abstract

Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification. This article reviews the basic principles of TRT and discusses the latest development in radionuclide imaging techniques for different theranostic agents, with emphasis on their potential to improve personalized TRT dosimetry.

KeywordNuclear Medicine Imaging Targeted Radionuclide Therapy Internal Dosimetry Theranostic Agents
DOI10.7150/thno.19782
URLView the original
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000413224300014
PublisherIVYSPRING INT PUBL
The Source to ArticleWOS
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被引频次[WOS]:10   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Affiliation1.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau SAR, China
2.Dept of Radiology and Nuclear medicine, Ghent University, De Pintelaan 185 9000 Gent, Belgium
3.AZ Maria Middelares, Buiten-Ring-Sint-Denijs 30, 9000 Gent, Belgium
4.Dept of Nuclear Medicine, UZ Ghent-Ghent University, St-Pietersnieuwstraat 41, 9000 Gent, Belgium
5.MEDISIP-ELIS-IBITECH-IMEC, Ghent University, St-Pietersnieuwstraat 41, 9000 Gent, Belgium
6.Faculty of Health Sciences, University of Macau, Macau SAR, China
First Author AffilicationFaculty of Science and Technology
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Li, Tiantian,Ao, Edwin C. I.,Lambert, Bieke,et al. Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review[J]. THERANOSTICS,2017,7(18):4551-4565.
APA Li, Tiantian,Ao, Edwin C. I.,Lambert, Bieke,Brans, Boudewijn,Vandenberghe, Stefaan,&Mok, Greta S. P..(2017).Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review.THERANOSTICS,7(18),4551-4565.
MLA Li, Tiantian,et al."Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry - Technical Review".THERANOSTICS 7.18(2017):4551-4565.
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