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Recent applications of hydrophilic interaction liquid chromatography in pharmaceutical analysis
Zhang, Qian1; Yang, Feng-Qing1; Ge, Liya2; Hu, Yuan-Jia3; Xia, Zhi-Ning1
2017-01
Source PublicationJOURNAL OF SEPARATION SCIENCE
ISSN1615-9306
Volume40Issue:1Pages:49-80
Other Abstract

Hydrophilic interaction liquid chromatography, an alternative liquid chromatography mode, is of particular interest in separating hydrophilic and polar ionic compounds. Compared with traditional liquid chromatography techniques, hydrophilic interaction liquid chromatography offers specific advantages mainly including: (1) relatively green and water-soluble mobile phase composition, which enhances the solubility of hydrophilic and polar ionic compounds; (2) no need for ion-pairing reagents and high content of organic solvent, which benefits mass spectrometry detection; (3) high orthogonality to reverse-phase liquid chromatography, well adapted to two-dimensional liquid chromatography for complicated samples. Therefore, hydrophilic interaction liquid chromatography has been rapidly developed in many areas over the past decades. This review summarizes the recent progress (from 2012 to July 2016) of hydrophilic interaction liquid chromatography in pharmaceutical analysis, with the focus on detecting chemical drugs in various matrices, charactering active compounds of natural products and assessing biotherapeutics through typical structure unit. Moreover, the retention mechanism and behavior of analytes in hydrophilic interaction liquid chromatography as well as some novel hydrophilic interaction liquid chromatography columns used for pharmaceutical analysis are also described.

KeywordBiopharmaceuticals Chemical Drugs Hydrophilic Interaction Liquid Chromatography Natural Products
DOI10.1002/jssc.201600843
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000393604600003
PublisherWILEY-V C H VERLAG GMBH
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:31   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYang, Feng-Qing
Affiliation1.School of Chemistry andChemical Engineering,Chongqing University,Chongqing, P. R. China
2.Residues and ResourceReclamation Centre, NanyangEnvironment and WaterResearch Institute, NanyangTechnological University,Singapore
3.State Key Laboratory of QualityResearch in Chinese Medicine,Institute of Chinese MedicalSciencesUniversity of Macau,Macao, P. R. China
Recommended Citation
GB/T 7714
Zhang, Qian,Yang, Feng-Qing,Ge, Liya,et al. Recent applications of hydrophilic interaction liquid chromatography in pharmaceutical analysis[J]. JOURNAL OF SEPARATION SCIENCE,2017,40(1):49-80.
APA Zhang, Qian,Yang, Feng-Qing,Ge, Liya,Hu, Yuan-Jia,&Xia, Zhi-Ning.(2017).Recent applications of hydrophilic interaction liquid chromatography in pharmaceutical analysis.JOURNAL OF SEPARATION SCIENCE,40(1),49-80.
MLA Zhang, Qian,et al."Recent applications of hydrophilic interaction liquid chromatography in pharmaceutical analysis".JOURNAL OF SEPARATION SCIENCE 40.1(2017):49-80.
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