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A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region: Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging
Zhang, Jian1; Chen, Haobin2; Zhou, Ting3; Wang, Limei4,5; Gao, Duyang1; Zhang, Xuanjun1; Liu, Yubin1; Wu, Changfeng2; Yuan, Zhen1
2017-01
Source PublicationNANO RESEARCH
ISSN1998-0124
Volume10Issue:1Pages:64-76
Abstract

As a hybrid imaging technique, photoacoustic imaging (PAI) can provide multiscale morphological information of tissues, and the use of multi-spectral PAI (MSPAI) can recover the spatial distribution of chromophores of interest, such as hemoglobin within tissues. Herein, we developed a contrast agent that can very effectively combine multiscale PAI with MSPAI for a more comprehensive characterization of complex biological tissues. Specifically, we developed novel PIID-DTBT based semi-conducting polymer dots (Pdots) that show broad and strong optical absorption in the visible-light region (500-700 nm). The performances of gold nanoparticles (GNPs) and gold nanorods (GNRs), which have been verified as excellent photoacoustic contrast agents, were compared with that of the Pdots based on the multiscale PAI system. Both ex vivo and in vivo experiments demonstrated that the Pdots have better photoacoustic conversion efficiency at 532 nm than GNPs and showed similar photoacoustic performance with GNRs at 700 nm at the same mass concentration. Photostability and toxicity tests demonstrated that the Pdots are photostable and biocompatible. More importantly, an in vivo MSPAI experiment indicated that the Pdots have better photoacoustic performance than the blood and therefore the signals can be accurately extracted from the background of vascular-rich tissues. Our work demonstrates the great potential of Pdots as highly effective contrast agents for the precise localization of lesions relative to the blood vessels based on multiscale PAI and MSPAI.

KeywordNanoparticles Polymer Dots Contrast Agents Photoacoustic Imaging Multiscale Imaging Multi-spectral Imaging
DOI10.1007/s12274-016-1266-8
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000390066000006
PublisherTSINGHUA UNIV PRESS
The Source to ArticleWOS
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Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China
2.State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Jilin, China
3.College of Optoelectronic Engineeringm, Shenzhen University, Shenzhen, China
4.College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
5.Center for Drug Non-clinical Evaluation and Research, Guangdong Biological Resources Institute, Guangdong Academy of Sciences, Guangzhou, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhang, Jian,Chen, Haobin,Zhou, Ting,et al. A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region: Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging[J]. NANO RESEARCH,2017,10(1):64-76.
APA Zhang, Jian.,Chen, Haobin.,Zhou, Ting.,Wang, Limei.,Gao, Duyang.,...&Yuan, Zhen.(2017).A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region: Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging.NANO RESEARCH,10(1),64-76.
MLA Zhang, Jian,et al."A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region: Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging".NANO RESEARCH 10.1(2017):64-76.
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