UM
iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability
Gao, Fei; Zhang, Jinming; Fu, Chaomei; Xie, Xiaoming; Peng, Fu; You, Jieshu; Tang, Hailin; Wang, Zhiyu; Li, Peng; Chen, Jianping
2017
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume12Pages:4147-4162
AbstractIsoliquiritigenin (ISL), a natural anti-breast cancer dietary compound, has poor delivery characteristics and low bioavailability. In order to promote the therapeutic outcome of ISL, a tumor-targeting lipid-polymer hybrid nanoparticle (NP) system modified by tumor-homing iRGD peptides has been developed. The hybrid NPs were prepared by a modified single-step nanoprecipitation method to encapsulate ISL. iRGD peptides were anchored on the surface by a postinsertion method (ISL-iRGD NPs). The stable lipid-polymer structure of ISL-iRGD NPs, with high encapsulation and loading efficiency, was confirmed. Compared to free ISL and non-iRGD-modified counterparts, ISL-iRGD NPs showed higher cytotoxicity and cell apoptosis against the different type of breast cancer cells. This was attributable to higher cellular accumulation mediated by the iRGD-integrin recognition and the nanoscale effect. More importantly, based on the active tumor-tissue accumulation by iRGD peptides and the prolonged in vivo circulation by the stealth nanostructure, ISL-iRGD NPs displayed higher tumor-growth inhibition efficiency in 4T1-bearing breast-tumor mouse models. Therefore, the constructed iRGD modified lipid-polymer hybrid NPs would provide a promising drug-delivery strategy to improve ISL in anti-breast cancer efficacy.
Keywordisoliquiritigenin iRGD lipid-polymer hybrid NPs breast cancer
DOI10.2147/IJN.S134148
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000402665500002
PublisherDOVE MEDICAL PRESS LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:19   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Gao, Fei,Zhang, Jinming,Fu, Chaomei,et al. iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:4147-4162.
APA Gao, Fei.,Zhang, Jinming.,Fu, Chaomei.,Xie, Xiaoming.,Peng, Fu.,...&Chen, Jianping.(2017).iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,4147-4162.
MLA Gao, Fei,et al."iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):4147-4162.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gao, Fei]'s Articles
[Zhang, Jinming]'s Articles
[Fu, Chaomei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gao, Fei]'s Articles
[Zhang, Jinming]'s Articles
[Fu, Chaomei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gao, Fei]'s Articles
[Zhang, Jinming]'s Articles
[Fu, Chaomei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.