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Omega-3 polyunsaturated fatty acids promote amyloid-beta clearance from the brain through mediating the function of the glymphatic system
Ren, Huixia1; Luo, Chuanming2; Feng, Yanqing3; Yao, Xiaoli3; Shi, Zhe1; Liang, Fengyin2; Kang, Jing X.4; Wan, Jian-Bo1; Pei, Zhong3; Su, Huanxing1
2017-01
Source PublicationFASEB JOURNAL
ISSN0892-6638
Volume31Issue:1Pages:282-293
Abstract

Impairment of amyloid-beta (A beta) clearance leads to A beta accumulation in the brain during the development of Alzheimer's disease (AD). Strategies that can restore or improve the clearance function hold great promise in delaying or preventing the onset of AD. Here, we show that n-3 polyunsaturated fatty acids (PUFAs), by use of fat-1 transgenic mice and oral administration of fish oil, significantly promote interstitial A beta clearance from the brain and resist A beta injury. Such beneficial effects were abolished in Aqp4-knockout mice, suggesting that the AQP4-dependent glymphatic system is actively involved in the promoting the effects of n-3 PUFAs on the clearance of extracellular A beta. Imaging on clarified brain tissues clearly displayed that n-3 PUFAs markedly inhibit the activation of astrocytes and protect the AQP4 polarization in the affected brain region after A beta injection. The results of the present study prove a novel mechanism by which n-3 PUFAs exert protective roles in reducing A beta accumulation via mediating the glymphatic system function.-Ren, H., Luo, C., Feng, Y., Yao, X., Shi, Z., Liang, F., Kang, J. X., Wan, J.-B., Pei, Z., Su, H. Omega-3 polyunsaturated fatty acids promote amyloid-b clearance from the brain through mediating the function of the glymphatic system.

KeywordExtracellular Solutes Clearance Dha Perivascular Pathways Fish Oil Aqp4 Polarization
DOI10.1096/fj.201600896
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biology ; Cell Biology
WOS IDWOS:000392177600027
PublisherFEDERATION AMER SOC EXP BIOL
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:29   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSu, Huanxing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Neurology, Second Clinical Medical College, Guangdong Medical University, Dongguan, China
3.Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
4.Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ren, Huixia,Luo, Chuanming,Feng, Yanqing,et al. Omega-3 polyunsaturated fatty acids promote amyloid-beta clearance from the brain through mediating the function of the glymphatic system[J]. FASEB JOURNAL,2017,31(1):282-293.
APA Ren, Huixia.,Luo, Chuanming.,Feng, Yanqing.,Yao, Xiaoli.,Shi, Zhe.,...&Su, Huanxing.(2017).Omega-3 polyunsaturated fatty acids promote amyloid-beta clearance from the brain through mediating the function of the glymphatic system.FASEB JOURNAL,31(1),282-293.
MLA Ren, Huixia,et al."Omega-3 polyunsaturated fatty acids promote amyloid-beta clearance from the brain through mediating the function of the glymphatic system".FASEB JOURNAL 31.1(2017):282-293.
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