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Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for In Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging
Gao, Duyang1; Sheng, Zonghai2; Liu, Yubin1; Hu, Dehong2; Zhang, Jian1; Zhang, Xuanjun1; Zheng, Hairong2; Yuan, Zhen1
2017-01
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
Volume6Issue:1
Abstract

Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, gadolinium ions chelated diethylenetriaminepentaacetic acid is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the as-obtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual-modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel as-prepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new avenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.

DOI10.1002/adhm.201601094
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, bioMaterials
WOS IDWOS:000393591900013
PublisherWILEY
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, P. R. China.
2.Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Gao, Duyang,Sheng, Zonghai,Liu, Yubin,et al. Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for In Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging[J]. ADVANCED HEALTHCARE MATERIALS,2017,6(1).
APA Gao, Duyang.,Sheng, Zonghai.,Liu, Yubin.,Hu, Dehong.,Zhang, Jian.,...&Yuan, Zhen.(2017).Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for In Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging.ADVANCED HEALTHCARE MATERIALS,6(1).
MLA Gao, Duyang,et al."Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for In Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging".ADVANCED HEALTHCARE MATERIALS 6.1(2017).
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