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Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation
Liu, Yuling1,2; Fu, Sai1; Lin, Longfei1; Cao, Yuhong3; Xie, Xi3; Yu, Hua2; Chen, Meiwan2; Li, Hui1
2017
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume12Pages:2635-2644
Abstract

Pluronic F127 (F127), an amphiphilic triblock copolymer, has been shown to have significant potential for drug delivery, as it is able to incorporate hydrophobic drugs and self-assemble into nanosize micelles. However, it suffers from dissociation upon dilution owing to the relatively high critical micelle concentration and lack of stimuli-responsive behavior. Here, we synthesized the a-tocopherol (TOC) modified F127 polymer (F127-SS-TOC) via a redox-sensitive disulfide bond between F127 and TOC, which formed stable micelles at relatively low critical micelle concentration and was sensitive to the intracellular redox environment. The particle size and zeta potential of the F127-SS-TOC micelles were 51.87 +/- 6.39 nm and -8.43 +/- 2.27 mV, respectively, and little changes in both particle size and zeta potential were observed within 7 days at room temperature. With 10 mM dithiothreitol stimulation, the F127-SS-TOC micelles rapidly dissociated followed by a significant change in size, which demonstrated a high reduction sensitivity of the micelles. In addition, the micelles showed a high hemocompatibility even at a high micelle concentration (1,000 mu g/mL). Low cytotoxicity of the F127-SS-TOC micelles at concentrations ranging from 12.5 mu g/mL to 200 mu g/mL was also found on both Bel 7402 and L02 cells. Overall, our results demonstrated F127-SS-TOC micelles as a stable and safe aqueous formulation with a considerable potential for drug delivery.

KeywordPluronic F127 Tocopherol Reduction Sensitivity Micelles Hemolysis
DOI10.2147/IJN.S122746
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000398661900002
PublisherDOVE MEDICAL PRESS LTD
The Source to ArticleWOS
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China
3.Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu, Yuling,Fu, Sai,Lin, Longfei,et al. Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:2635-2644.
APA Liu, Yuling.,Fu, Sai.,Lin, Longfei.,Cao, Yuhong.,Xie, Xi.,...&Li, Hui.(2017).Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,2635-2644.
MLA Liu, Yuling,et al."Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):2635-2644.
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