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Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
Li, Zeyong1; Cai, Yuee2; Zhao, Yiqiao1; Yu, Hua2; Zhou, Haiyu3; Chen, Meiwan2
2017
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume12Pages:6595-6604
Abstract

Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(epsilon-caprolactone)-pluronic F68-poly(epsilon-caprolactone)/poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,L-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light. MIT-PFP/PPP mixed micelles showed effective interaction with near-infrared light at the wavelength of 660 nm and exerted great cytotoxicity in MCF-7/ADR cells with irradiation. Furthermore, MIT-PFP/PPP mixed micelles could improve reactive oxygen species (ROS) levels, decrease P-glycoprotein activity, and increase the cellular uptake of drugs with improved intracellular drug concentrations, which induced cell apoptosis in MCF-7/ADR cells under irradiation, despite MDR effect, as indicated by the increased level of cleaved poly ADP-ribose polymerase. These findings suggested that MIT-PFP/PPP mixed micelles may become a promising strategy to effectively reverse the MDR effect via photodynamic therapy in breast cancer.

KeywordMitoxantrone Polymeric Mixed Micelles Multidrug Resistance Photodynamic Therapy Breast Cancer
DOI10.2147/IJN.S138235
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000409298900002
PublisherDOVE MEDICAL PRESS LTD
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Laboratory Medicine, Guangdong No 2 Provincial People’s Hospital, Guangzhou, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
3.Department of Thoracic Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, South China University of Technology, Guangzhou, China
Recommended Citation
GB/T 7714
Li, Zeyong,Cai, Yuee,Zhao, Yiqiao,et al. Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:6595-6604.
APA Li, Zeyong,Cai, Yuee,Zhao, Yiqiao,Yu, Hua,Zhou, Haiyu,&Chen, Meiwan.(2017).Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,6595-6604.
MLA Li, Zeyong,et al."Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):6595-6604.
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