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A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays
Lei, Ka-Meng1; Heidari, Hadi2; Mak, Pui-In1; Law, Man-Kay1; Maloberti, Franco2; Martins, Rui P.1
2017-01
Source PublicationIEEE JOURNAL OF SOLID-STATE CIRCUITS
ISSN0018-9200
Volume52Issue:1Pages:284-297
Abstract

We report a micro-nuclear magnetic resonance (NMR) system compatible with multi-type biological/chemical lab-on-a- chip assays. Unified in a handheld scale (dimension: 14 x 6 x 11 cm(3), weight: 1.4 kg), the system is capable to detect < 100 pM of Enterococcus faecalis derived DNA from a 2.5 mu L sample. The key components are a portable magnet (0.46 T, 1.25 kg) for nucleus magnetization, a system PCB for I/O interface, an FPGA for system control, a current driver for trimming the magnetic (B) field, and a silicon chip fabricated in 0.18 mu m CMOS. The latter, integrated with a current-mode vertical Hall sensor and a low-noise readout circuit, facilitates closed-loop B-field stabilization (2 mT -> 0.15 mT), which otherwise fluctuates with temperature or sample displacement. Together with a dynamic-B-field transceiver with a planar coil for micro-NMR assay and thermal control, the system demonstrates: 1) selective biological target pinpointing; 2) protein state analysis; and 3) solvent-polymer dynamics, suitable for healthcare, food and colloidal applications, respectively. Compared to a commercial NMR-assay product (Bruker mq-20), this platform greatly reduces the sample consumption (120x), hardware volume (175x), and weight (96x).

KeywordBaseband Biological Biosensor Chemicalcmos Deoxyribonucleic Acid (Dna) Filter Hall Sensor Immunoglobulin Lab-on-a-chip Low-noise Amplifier (Lna) Magnetic Sensing Nuclear Magnetic Resonance (Nmr) Pointof-care Polymer Power Amplifier (Pa) Protein Radio Frequency (Rf) Receiver (Rx) Transceiver (Trx) Transimpedance Amplifier (Tia) Transmitter (Tx)
DOI10.1109/JSSC.2016.2591551
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Electrical & Electronic
WOS IDWOS:000395641800025
PublisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF MICROELECTRONICS
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Corresponding AuthorMak, Pui-In
Affiliation1.State-Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECE, University of Macau, Macao, China
2.University of Pavia, Pavia, Italy
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Lei, Ka-Meng,Heidari, Hadi,Mak, Pui-In,et al. A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays[J]. IEEE JOURNAL OF SOLID-STATE CIRCUITS,2017,52(1):284-297.
APA Lei, Ka-Meng,Heidari, Hadi,Mak, Pui-In,Law, Man-Kay,Maloberti, Franco,&Martins, Rui P..(2017).A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays.IEEE JOURNAL OF SOLID-STATE CIRCUITS,52(1),284-297.
MLA Lei, Ka-Meng,et al."A Handheld High-Sensitivity Micro-NMR CMOS Platform With B-Field Stabilization for Multi-Type Biological/Chemical Assays".IEEE JOURNAL OF SOLID-STATE CIRCUITS 52.1(2017):284-297.
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